Gene description for DYNC2H1
Gene name dynein, cytoplasmic 2, heavy chain 1
Gene symbol DYNC2H1
Other names/aliases ATD3
DHC1b
DHC2
DNCH2
DYH1B
SRPS2B
SRTD3
hdhc11
Species Homo sapiens
 Database cross references - DYNC2H1
ExoCarta ExoCarta_79659
Entrez Gene 79659
HGNC 2962
MIM 603297
UniProt Q8NCM8  
 DYNC2H1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for DYNC2H1
Molecular Function
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IEA
    microtubule motor activity GO:0003777 IEA
    motor activity GO:0003774 NAS
Biological Process
    embryonic limb morphogenesis GO:0030326 IEA
    organelle organization GO:0006996 TAS
    positive regulation of smoothened signaling pathway GO:0045880 IEA
    dorsal/ventral pattern formation GO:0009953 IEA
    determination of left/right symmetry GO:0007368 IEA
    asymmetric protein localization GO:0008105 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    spinal cord motor neuron differentiation GO:0021522 IEA
    Golgi organization GO:0007030 IDA
    intraciliary retrograde transport GO:0035721 IEA
    protein processing GO:0016485 IEA
    cilium assembly GO:0042384 IEA
    forebrain development GO:0030900 IEA
Subcellular Localization
    microtubule GO:0005874 IDA
    cytosol GO:0005829 TAS
    apical part of cell GO:0045177 IEA
    extracellular exosome GO:0070062 IDA
    ciliary tip GO:0097542 TAS
    dynein complex GO:0030286 IEA
    primary cilium GO:0072372 TAS
    Golgi apparatus GO:0005794 IDA
    axoneme GO:0005930 IEA
    plasma membrane GO:0005886 IEA
    motile primary cilium GO:0031512 IEA
 Experiment description of studies that identified DYNC2H1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DYNC2H1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 D2LIC  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which DYNC2H1 is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Intraflagellar transport TAS Reactome
MHC class II antigen presentation TAS Reactome





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