Gene description for HIC2
Gene name hypermethylated in cancer 2
Gene symbol HIC2
Other names/aliases HRG22
ZBTB30
ZNF907
Species Homo sapiens
 Database cross references - HIC2
ExoCarta ExoCarta_23119
Entrez Gene 23119
HGNC 18595
MIM 607712
UniProt Q96JB3  
 HIC2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for HIC2
Molecular Function
    protein C-terminus binding GO:0008022 IPI
    metal ion binding GO:0046872 IEA
    DNA binding GO:0003677 NAS
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 NAS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified HIC2 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for HIC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HIC2 is involved
No pathways found





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