Gene description for Cdh1
Gene name cadherin 1
Gene symbol Cdh1
Other names/aliases AA960649
E-cad
Ecad
L-CAM
UVO
Um
Species Mus musculus
 Database cross references - Cdh1
ExoCarta ExoCarta_12550
Vesiclepedia VP_12550
Entrez Gene 12550
UniProt P09803  
 Cdh1 identified in exosomes derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Cdh1
Molecular Function
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IBA
    beta-catenin binding GO:0008013 IDA
    beta-catenin binding GO:0008013 IPI
    beta-catenin binding GO:0008013 ISO
    cytoskeletal protein binding GO:0008092 IMP
    protein phosphatase binding GO:0019903 IPI
    protein domain specific binding GO:0019904 IPI
    ankyrin binding GO:0030506 ISO
    GTPase activating protein binding GO:0032794 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    alpha-catenin binding GO:0045294 IPI
    gamma-catenin binding GO:0045295 ISO
    cadherin binding GO:0045296 IBA
    cell adhesion molecule binding GO:0050839 ISO
    molecular adaptor activity GO:0060090 EXP
    molecular adaptor activity GO:0060090 IDA
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    cell morphogenesis GO:0000902 IBA
    in utero embryonic development GO:0001701 IMP
    trophectodermal cell differentiation GO:0001829 IMP
    epithelial cell morphogenesis GO:0003382 IMP
    cell-cell junction assembly GO:0007043 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    synapse assembly GO:0007416 IBA
    synapse assembly GO:0007416 ISO
    embryo implantation GO:0007566 IMP
    sensory perception of sound GO:0007605 IMP
    regulation of gene expression GO:0010468 ISO
    regulation of gene expression GO:0010468 ISS
    negative regulation of protein processing GO:0010955 IMP
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IBA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IDA
    cell migration GO:0016477 IBA
    protein metabolic process GO:0019538 IDA
    negative regulation of cell-cell adhesion GO:0022408 ISO
    positive regulation of cell-cell adhesion GO:0022409 IMP
    actin cytoskeleton organization GO:0030036 IMP
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of axon extension GO:0030517 ISO
    regulation of protein localization GO:0032880 IMP
    adherens junction organization GO:0034332 IBA
    adherens junction organization GO:0034332 ISO
    uterine epithelium development GO:0035847 IMP
    positive regulation of protein import into nucleus GO:0042307 ISO
    cell-cell adhesion mediated by cadherin GO:0044331 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 IMP
    positive regulation of DNA-templated transcription GO:0045893 ISO
    decidualization GO:0046697 IMP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    canonical Wnt signaling pathway GO:0060070 IMP
    intestinal epithelial cell development GO:0060576 IMP
    salivary gland cavitation GO:0060662 IMP
    regulation of branching involved in salivary gland morphogenesis GO:0060693 IMP
    establishment of skin barrier GO:0061436 IMP
    bicellular tight junction assembly GO:0070830 IMP
    cellular response to amino acid stimulus GO:0071230 IDA
    cellular response to lithium ion GO:0071285 ISO
    cellular response to indole-3-methanol GO:0071681 ISO
    protein localization to plasma membrane GO:0072659 IDA
    protein localization to plasma membrane GO:0072659 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    cochlea development GO:0090102 IDA
    cochlea development GO:0090102 IMP
    cell-cell adhesion GO:0098609 IMP
    cell-cell adhesion GO:0098609 ISO
    regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 ISO
    negative regulation of protein localization to plasma membrane GO:1903077 IMP
    regulation of protein localization to cell surface GO:2000008 IMP
    regulation of cysteine-type endopeptidase activity GO:2000116 IDA
    regulation of neuron migration GO:2001222 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IEA
    Golgi apparatus GO:0005794 IEA
    trans-Golgi network GO:0005802 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    microvillus GO:0005902 IDA
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    adherens junction GO:0005912 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cell surface GO:0009986 IDA
    actin cytoskeleton GO:0015629 ISO
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IDA
    lateral plasma membrane GO:0016328 ISO
    catenin complex GO:0016342 IBA
    catenin complex GO:0016342 IDA
    catenin complex GO:0016342 IMP
    catenin complex GO:0016342 ISO
    flotillin complex GO:0016600 IBA
    flotillin complex GO:0016600 IDA
    flotillin complex GO:0016600 ISO
    lamellipodium GO:0030027 ISO
    cell junction GO:0030054 ISO
    desmosome GO:0030057 IEA
    axon GO:0030424 IDA
    cortical actin cytoskeleton GO:0030864 ISO
    node of Ranvier GO:0033268 IDA
    lateral loop GO:0043219 IDA
    Schmidt-Lanterman incisure GO:0043220 IDA
    apical junction complex GO:0043296 IBA
    apical junction complex GO:0043296 IDA
    apical junction complex GO:0043296 ISO
    axon terminus GO:0043679 IDA
    apical part of cell GO:0045177 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    cell periphery GO:0071944 IDA
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Cdh1 in exosomes
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Cdh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 JUP 3728
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
3 SLIRP 81892
Affinity Capture-MS Homo sapiens
4 Phlpp1  
Co-fractionation Mus musculus
5 HADHB 3032
Affinity Capture-MS Homo sapiens
6 Myf5  
Affinity Capture-Western Mus musculus
7 Gna13 14674
Affinity Capture-Western Mus musculus
8 Ctnnb1 12387
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
9 MACF1 23499
Affinity Capture-MS Homo sapiens
10 Itgae  
Co-fractionation Mus musculus
11 CDH10  
Affinity Capture-MS Homo sapiens
12 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
13 Ctnnd1 12388
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
14 CTNNB1 1499
Affinity Capture-MS Homo sapiens
15 Psen1  
Affinity Capture-Western Mus musculus
16 SLC1A5 6510
Affinity Capture-MS Homo sapiens
17 Chaf1a  
Affinity Capture-MS Mus musculus
18 Dnmt1 13433
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
19 KLHL7  
Affinity Capture-MS Homo sapiens
20 Ctnna1 12385
Affinity Capture-Western Mus musculus
21 PRRC2B  
Affinity Capture-MS Homo sapiens
22 TBP  
Affinity Capture-MS Homo sapiens
23 LRPPRC 10128
Affinity Capture-MS Homo sapiens
24 ZBTB48  
Affinity Capture-MS Homo sapiens
25 LZTS2 84445
Affinity Capture-MS Homo sapiens
26 Ptprq  
Affinity Capture-Western Mus musculus
27 ARVCF 421
Affinity Capture-MS Homo sapiens
28 Msantd3  
Co-fractionation Mus musculus
29 Pou5f1  
Affinity Capture-Western Mus musculus
30 PKP4 8502
Affinity Capture-MS Homo sapiens
31 MROH1 727957
Affinity Capture-MS Homo sapiens
32 Scrib 105782
Co-fractionation Mus musculus
33 CTNNA1 1495
Affinity Capture-MS Homo sapiens
34 Marveld2  
Co-fractionation Mus musculus
35 PCNXL3 399909
Affinity Capture-MS Homo sapiens
36 CTNND1 1500
Affinity Capture-MS Homo sapiens
37 HMGB2 3148
Affinity Capture-MS Homo sapiens
38 Skp2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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