Gene description for RGCC
Gene name regulator of cell cycle
Gene symbol RGCC
Other names/aliases C13orf15
RGC-32
RGC32
bA157L14.2
Species Homo sapiens
 Database cross references - RGCC
ExoCarta ExoCarta_28984
Vesiclepedia VP_28984
Entrez Gene 28984
HGNC 20369
MIM 610077
UniProt Q9H4X1  
 RGCC identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RGCC
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    protein kinase binding GO:0019901 ISS
    protein kinase activator activity GO:0030295 IBA
    protein kinase activator activity GO:0030295 IDA
    R-SMAD binding GO:0070412 IPI
Biological Process
    negative regulation of exit from mitosis GO:0001100 IDA
    negative regulation of cytokine production GO:0001818 IMP
    positive regulation of cytokine production GO:0001819 IMP
    negative regulation of endothelial cell proliferation GO:0001937 IDA
    positive regulation of extracellular matrix constituent secretion GO:0003331 IDA
    complement activation GO:0006956 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of epithelial to mesenchymal transition GO:0010718 IDA
    positive regulation of epithelial to mesenchymal transition GO:0010718 IMP
    negative regulation of angiogenesis GO:0016525 IDA
    positive regulation of collagen biosynthetic process GO:0032967 IDA
    negative regulation of blood vessel endothelial cell migration GO:0043537 IDA
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 IDA
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 IMP
    positive regulation of mitotic nuclear division GO:0045840 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    positive regulation of stress fiber assembly GO:0051496 IDA
    cellular response to hypoxia GO:0071456 IMP
    fibroblast activation GO:0072537 ISS
    negative regulation of fibroblast growth factor production GO:0090272 IDA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP
    positive regulation of extracellular matrix assembly GO:1901203 IDA
    negative regulation of mitotic cell cycle phase transition GO:1901991 IDA
    negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 IDA
    positive regulation of endothelial cell apoptotic process GO:2000353 IDA
    positive regulation of DNA biosynthetic process GO:2000573 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified RGCC in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RGCC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK1 983
Biochemical Activity Homo sapiens
2 SMAD2 4087
Affinity Capture-Western Homo sapiens
3 TLN2 83660
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 TRAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VASP 7408
Affinity Capture-MS Homo sapiens
6 AKT1 207
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 SMAD3 4088
Affinity Capture-Western Homo sapiens
8 TLN1 7094
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CARS2 79587
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PLK1 5347
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
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