Gene description for Bax
Gene name	BCL2-associated X protein
Gene symbol	Bax
Other names/aliases	-
Species	Mus musculus
Database cross references - Bax
ExoCarta	ExoCarta_12028
Entrez Gene	12028
UniProt	Q07813
Bax identified in exosomes derived from the following tissue/cell type
Pancreatic cells	19351151

Gene ontology annotations for Bax

Molecular Function     BH domain binding GO:0051400 ISO     channel activity GO:0015267 ISO     BH3 domain binding GO:0051434 ISO     heat shock protein binding GO:0031072 ISO     protein homodimerization activity GO:0042803 ISO     chaperone binding GO:0051087 ISO     protein binding GO:0005515 IPI     protein heterodimerization activity GO:0046982 ISO     lipid binding GO:0008289 ISO     protein complex binding GO:0032403 ISO     identical protein binding GO:0042802 ISO Biological Process     response to toxic substance GO:0009636 ISO     response to ionizing radiation GO:0010212 IMP     release of cytochrome c from mitochondria GO:0001836 ISO     regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IMP     post-embryonic development GO:0009791 IGI     response to salt stress GO:0009651 IGI     germ cell development GO:0007281 IGI     cellular response to DNA damage stimulus GO:0006974 IMP     homeostasis of number of cells within a tissue GO:0048873 IMP     mitochondrial fusion GO:0008053 ISO     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IGI     regulation of mammary gland epithelial cell proliferation GO:0033599 IMP     nervous system development GO:0007399 IMP     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA     regulation of cell cycle GO:0051726 IGI     regulation of apoptotic process GO:0042981 IEA     cellular response to UV GO:0034644 IGI     vagina development GO:0060068 IGI     regulation of nitrogen utilization GO:0006808 IGI     activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 ISO     regulation of protein heterodimerization activity GO:0043497 ISO     positive regulation of apoptotic process involved in mammary gland involution GO:0060058 IMP     cellular response to organic substance GO:0071310 IDA     transmembrane transport GO:0055085 IBA     release of matrix enzymes from mitochondria GO:0032976 ISO     B cell homeostasis GO:0001782 IMP     protein oligomerization GO:0051259 ISO     regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 IMP     outer mitochondrial membrane organization GO:0007008 ISO     regulation of neuron apoptotic process GO:0043523 IMP     regulation of protein homodimerization activity GO:0043496 ISO     negative regulation of protein binding GO:0032091 ISO     inner mitochondrial membrane organization GO:0007007 ISO     positive regulation of calcium ion transport into cytosol GO:0010524 IGI     retina development in camera-type eye GO:0060041 IMP     B cell apoptotic process GO:0001783 ISO     response to gamma radiation GO:0010332 IMP     positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO     protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 IMP     regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 IGI     sex differentiation GO:0007548 IMP     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISO     positive regulation of B cell apoptotic process GO:0002904 IGI     development of secondary sexual characteristics GO:0045136 IMP     ovarian follicle development GO:0001541 IMP     positive regulation of protein oligomerization GO:0032461 ISO     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 IMP     apoptotic process GO:0006915 ISO     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP     retinal cell programmed cell death GO:0046666 IMP     B cell receptor apoptotic signaling pathway GO:1990117 ISO     ectopic germ cell programmed cell death GO:0035234 IMP     thymocyte apoptotic process GO:0070242 IGI     retinal cell apoptotic process GO:1990009 ISO     response to wounding GO:0009611 IMP     apoptotic mitochondrial changes GO:0008637 ISO     apoptotic signaling pathway GO:0097190 ISO     kidney development GO:0001822 IGI     B cell negative selection GO:0002352 IGI     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO     negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IGI     limb morphogenesis GO:0035108 IGI     homeostasis of number of cells GO:0048872 IMP     myeloid cell homeostasis GO:0002262 IGI     negative regulation of cell proliferation GO:0008285 IMP     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP     positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 ISO     apoptotic process involved in patterning of blood vessels GO:1902262 IGI     fertilization GO:0009566 IGI     apoptotic process involved in embryonic digit morphogenesis GO:1902263 IGI     cerebral cortex development GO:0021987 IMP     transformed cell apoptotic process GO:0006927 ISO     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     positive regulation of apoptotic DNA fragmentation GO:1902512 ISO     extrinsic apoptotic signaling pathway GO:0097191 ISO     spermatid differentiation GO:0048515 IMP     glycosphingolipid metabolic process GO:0006687 IMP     protein homooligomerization GO:0051260 ISO     post-embryonic camera-type eye morphogenesis GO:0048597 IGI     spermatogenesis GO:0007283 IMP     negative regulation of fibroblast proliferation GO:0048147 IMP     male gonad development GO:0008584 IMP     odontogenesis of dentin-containing tooth GO:0042475 IGI     leukocyte homeostasis GO:0001776 IGI     B cell homeostatic proliferation GO:0002358 IMP     neuron migration GO:0001764 IMP     positive regulation of neuron apoptotic process GO:0043525 ISO     hypothalamus development GO:0021854 IMP     positive regulation of developmental pigmentation GO:0048087 IGI     blood vessel remodeling GO:0001974 IGI     positive regulation of apoptotic process GO:0043065 ISO     neuron apoptotic process GO:0051402 IMP     T cell homeostatic proliferation GO:0001777 IMP     mitochondrion morphogenesis GO:0070584 IGI     intrinsic apoptotic signaling pathway GO:0097193 ISO     cell proliferation GO:0008283 IGI     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO     positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 IGI     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO     negative regulation of peptidyl-serine phosphorylation GO:0033137 IGI     response to axon injury GO:0048678 IMP     negative regulation of neuron apoptotic process GO:0043524 IDA     negative regulation of apoptotic signaling pathway GO:2001234 IGI     regulation of mitochondrial membrane potential GO:0051881 IDA     cellular respiration GO:0045333 ISO     Sertoli cell proliferation GO:0060011 IGI     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 ISO Subcellular Localization     mitochondrion GO:0005739 ISO     nuclear envelope GO:0005635 ISO     BAX complex GO:0097144 ISO     intracellular GO:0005622 IGI     extracellular exosome GO:0070062 ISO     Bcl-2 family protein complex GO:0097136 ISO     nucleus GO:0005634 ISO     endoplasmic reticulum membrane GO:0005789 ISO     cytoplasm GO:0005737 ISO     integral component of membrane GO:0016021 ISS     mitochondrial permeability transition pore complex GO:0005757 ISO     mitochondrial membrane GO:0031966 ISO     mitochondrial outer membrane GO:0005741 ISO     cell GO:0005623 IGI     membrane GO:0016020 ISO     pore complex GO:0046930 ISO     cytosol GO:0005829 ISO     endoplasmic reticulum GO:0005783 ISO