Gene description for Bax
Gene name BCL2-associated X protein
Gene symbol Bax
Other names/aliases -
Species Mus musculus
 Database cross references - Bax
ExoCarta ExoCarta_12028
Entrez Gene 12028
UniProt Q07813  
 Bax identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Bax
Molecular Function
    BH domain binding GO:0051400 ISO
    channel activity GO:0015267 ISO
    BH3 domain binding GO:0051434 ISO
    heat shock protein binding GO:0031072 ISO
    protein homodimerization activity GO:0042803 ISO
    chaperone binding GO:0051087 ISO
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 ISO
    lipid binding GO:0008289 ISO
    protein complex binding GO:0032403 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    response to toxic substance GO:0009636 ISO
    response to ionizing radiation GO:0010212 IMP
    release of cytochrome c from mitochondria GO:0001836 ISO
    regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IMP
    post-embryonic development GO:0009791 IGI
    response to salt stress GO:0009651 IGI
    germ cell development GO:0007281 IGI
    cellular response to DNA damage stimulus GO:0006974 IMP
    homeostasis of number of cells within a tissue GO:0048873 IMP
    mitochondrial fusion GO:0008053 ISO
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IGI
    regulation of mammary gland epithelial cell proliferation GO:0033599 IMP
    nervous system development GO:0007399 IMP
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA
    regulation of cell cycle GO:0051726 IGI
    regulation of apoptotic process GO:0042981 IEA
    cellular response to UV GO:0034644 IGI
    vagina development GO:0060068 IGI
    regulation of nitrogen utilization GO:0006808 IGI
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 ISO
    regulation of protein heterodimerization activity GO:0043497 ISO
    positive regulation of apoptotic process involved in mammary gland involution GO:0060058 IMP
    cellular response to organic substance GO:0071310 IDA
    transmembrane transport GO:0055085 IBA
    release of matrix enzymes from mitochondria GO:0032976 ISO
    B cell homeostasis GO:0001782 IMP
    protein oligomerization GO:0051259 ISO
    regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 IMP
    outer mitochondrial membrane organization GO:0007008 ISO
    regulation of neuron apoptotic process GO:0043523 IMP
    regulation of protein homodimerization activity GO:0043496 ISO
    negative regulation of protein binding GO:0032091 ISO
    inner mitochondrial membrane organization GO:0007007 ISO
    positive regulation of calcium ion transport into cytosol GO:0010524 IGI
    retina development in camera-type eye GO:0060041 IMP
    B cell apoptotic process GO:0001783 ISO
    response to gamma radiation GO:0010332 IMP
    positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO
    protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 IMP
    regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 IGI
    sex differentiation GO:0007548 IMP
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISO
    positive regulation of B cell apoptotic process GO:0002904 IGI
    development of secondary sexual characteristics GO:0045136 IMP
    ovarian follicle development GO:0001541 IMP
    positive regulation of protein oligomerization GO:0032461 ISO
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 IMP
    apoptotic process GO:0006915 ISO
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP
    retinal cell programmed cell death GO:0046666 IMP
    B cell receptor apoptotic signaling pathway GO:1990117 ISO
    ectopic germ cell programmed cell death GO:0035234 IMP
    thymocyte apoptotic process GO:0070242 IGI
    retinal cell apoptotic process GO:1990009 ISO
    response to wounding GO:0009611 IMP
    apoptotic mitochondrial changes GO:0008637 ISO
    apoptotic signaling pathway GO:0097190 ISO
    kidney development GO:0001822 IGI
    B cell negative selection GO:0002352 IGI
    mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IGI
    limb morphogenesis GO:0035108 IGI
    homeostasis of number of cells GO:0048872 IMP
    myeloid cell homeostasis GO:0002262 IGI
    negative regulation of cell proliferation GO:0008285 IMP
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 ISO
    apoptotic process involved in patterning of blood vessels GO:1902262 IGI
    fertilization GO:0009566 IGI
    apoptotic process involved in embryonic digit morphogenesis GO:1902263 IGI
    cerebral cortex development GO:0021987 IMP
    transformed cell apoptotic process GO:0006927 ISO
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP
    positive regulation of apoptotic DNA fragmentation GO:1902512 ISO
    extrinsic apoptotic signaling pathway GO:0097191 ISO
    spermatid differentiation GO:0048515 IMP
    glycosphingolipid metabolic process GO:0006687 IMP
    protein homooligomerization GO:0051260 ISO
    post-embryonic camera-type eye morphogenesis GO:0048597 IGI
    spermatogenesis GO:0007283 IMP
    negative regulation of fibroblast proliferation GO:0048147 IMP
    male gonad development GO:0008584 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IGI
    leukocyte homeostasis GO:0001776 IGI
    B cell homeostatic proliferation GO:0002358 IMP
    neuron migration GO:0001764 IMP
    positive regulation of neuron apoptotic process GO:0043525 ISO
    hypothalamus development GO:0021854 IMP
    positive regulation of developmental pigmentation GO:0048087 IGI
    blood vessel remodeling GO:0001974 IGI
    positive regulation of apoptotic process GO:0043065 ISO
    neuron apoptotic process GO:0051402 IMP
    T cell homeostatic proliferation GO:0001777 IMP
    mitochondrion morphogenesis GO:0070584 IGI
    intrinsic apoptotic signaling pathway GO:0097193 ISO
    cell proliferation GO:0008283 IGI
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
    positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 IGI
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO
    negative regulation of peptidyl-serine phosphorylation GO:0033137 IGI
    response to axon injury GO:0048678 IMP
    negative regulation of neuron apoptotic process GO:0043524 IDA
    negative regulation of apoptotic signaling pathway GO:2001234 IGI
    regulation of mitochondrial membrane potential GO:0051881 IDA
    cellular respiration GO:0045333 ISO
    Sertoli cell proliferation GO:0060011 IGI
    establishment or maintenance of transmembrane electrochemical gradient GO:0010248 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    nuclear envelope GO:0005635 ISO
    BAX complex GO:0097144 ISO
    intracellular GO:0005622 IGI
    extracellular exosome GO:0070062 ISO
    Bcl-2 family protein complex GO:0097136 ISO
    nucleus GO:0005634 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 ISS
    mitochondrial permeability transition pore complex GO:0005757 ISO
    mitochondrial membrane GO:0031966 ISO
    mitochondrial outer membrane GO:0005741 ISO
    cell GO:0005623 IGI
    membrane GO:0016020 ISO
    pore complex GO:0046930 ISO
    cytosol GO:0005829 ISO
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Bax in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Bax
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bax is involved
PathwayEvidenceSource
Activation, translocation and oligomerization of BAX IEA Reactome





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