Gene description for Bax
Gene name	BCL2-associated X protein
Gene symbol	Bax
Other names/aliases	-
Species	Mus musculus
Database cross references - Bax
ExoCarta	ExoCarta_12028
Vesiclepedia	VP_12028
Entrez Gene	12028
UniProt	Q07813
Bax identified in exosomes derived from the following tissue/cell type
Pancreatic cells	19351151

Gene ontology annotations for Bax

Molecular Function     protein binding GO:0005515 IPI     lipid binding GO:0008289 ISO     lipid binding GO:0008289 ISS     channel activity GO:0015267 IBA     channel activity GO:0015267 ISO     channel activity GO:0015267 ISS     Hsp70 protein binding GO:0030544 IDA     heat shock protein binding GO:0031072 ISO     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein-containing complex binding GO:0044877 ISO     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO     protein-folding chaperone binding GO:0051087 IPI     protein-folding chaperone binding GO:0051087 ISO     BH domain binding GO:0051400 ISO     BH3 domain binding GO:0051434 IEA     BH3 domain binding GO:0051434 ISO Biological Process     ovarian follicle development GO:0001541 IGI     ovarian follicle development GO:0001541 IMP     neuron migration GO:0001764 IMP     leukocyte homeostasis GO:0001776 IGI     T cell homeostatic proliferation GO:0001777 IMP     B cell homeostasis GO:0001782 IGI     B cell homeostasis GO:0001782 IMP     B cell apoptotic process GO:0001783 IGI     B cell apoptotic process GO:0001783 IGI     B cell apoptotic process GO:0001783 ISO     kidney development GO:0001822 IGI     release of cytochrome c from mitochondria GO:0001836 IBA     release of cytochrome c from mitochondria GO:0001836 IDA     release of cytochrome c from mitochondria GO:0001836 IGI     release of cytochrome c from mitochondria GO:0001836 ISO     blood vessel remodeling GO:0001974 IGI     myeloid cell homeostasis GO:0002262 IGI     B cell negative selection GO:0002352 IGI     B cell homeostatic proliferation GO:0002358 IMP     positive regulation of B cell apoptotic process GO:0002904 IGI     glycosphingolipid metabolic process GO:0006687 IMP     regulation of nitrogen utilization GO:0006808 IGI     apoptotic process GO:0006915 IDA     apoptotic process GO:0006915 IGI     apoptotic process GO:0006915 IMP     apoptotic process GO:0006915 IMP     apoptotic process GO:0006915 ISO     DNA damage response GO:0006974 IMP     mitochondrion organization GO:0007005 IGI     inner mitochondrial membrane organization GO:0007007 ISO     outer mitochondrial membrane organization GO:0007008 ISO     germ cell development GO:0007281 IGI     spermatogenesis GO:0007283 IGI     spermatogenesis GO:0007283 IMP     nervous system development GO:0007399 IMP     sex differentiation GO:0007548 IMP     mitochondrial fusion GO:0008053 IBA     mitochondrial fusion GO:0008053 IGI     mitochondrial fusion GO:0008053 ISO     mitochondrial fusion GO:0008053 ISS     cell population proliferation GO:0008283 IGI     negative regulation of cell population proliferation GO:0008285 IMP     male gonad development GO:0008584 IGI     male gonad development GO:0008584 IMP     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IGI     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 ISO     apoptotic mitochondrial changes GO:0008637 IDA     apoptotic mitochondrial changes GO:0008637 ISO     fertilization GO:0009566 IGI     response to wounding GO:0009611 IMP     response to toxic substance GO:0009636 IMP     response to toxic substance GO:0009636 ISO     response to salt stress GO:0009651 IGI     post-embryonic development GO:0009791 IGI     response to ionizing radiation GO:0010212 IGI     response to ionizing radiation GO:0010212 IMP     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 ISO     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 ISS     response to gamma radiation GO:0010332 IMP     positive regulation of calcium ion transport into cytosol GO:0010524 IGI     negative regulation of mitochondrial membrane potential GO:0010917 ISO     negative regulation of mitochondrial membrane potential GO:0010917 ISS     peptidyl-serine phosphorylation GO:0018105 IGI     hypothalamus development GO:0021854 IMP     cerebral cortex development GO:0021987 IMP     positive regulation of protein-containing complex assembly GO:0031334 ISO     positive regulation of protein-containing complex assembly GO:0031334 ISS     negative regulation of protein binding GO:0032091 ISO     negative regulation of protein binding GO:0032091 ISS     negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IGI     release of matrix enzymes from mitochondria GO:0032976 ISO     release of matrix enzymes from mitochondria GO:0032976 ISS     negative regulation of peptidyl-serine phosphorylation GO:0033137 IGI     regulation of mammary gland epithelial cell proliferation GO:0033599 IMP     cellular response to UV GO:0034644 IGI     limb morphogenesis GO:0035108 IGI     ectopic germ cell programmed cell death GO:0035234 IGI     ectopic germ cell programmed cell death GO:0035234 IMP     ectopic germ cell programmed cell death GO:0035234 IMP     odontogenesis of dentin-containing tooth GO:0042475 IGI     regulation of apoptotic process GO:0042981 IMP     regulation of apoptotic process GO:0042981 ISO     positive regulation of apoptotic process GO:0043065 IDA     positive regulation of apoptotic process GO:0043065 IGI     positive regulation of apoptotic process GO:0043065 IMP     positive regulation of apoptotic process GO:0043065 IMP     positive regulation of apoptotic process GO:0043065 ISO     regulation of neuron apoptotic process GO:0043523 IMP     negative regulation of neuron apoptotic process GO:0043524 IDA     positive regulation of neuron apoptotic process GO:0043525 IBA     positive regulation of neuron apoptotic process GO:0043525 IGI     positive regulation of neuron apoptotic process GO:0043525 IMP     positive regulation of neuron apoptotic process GO:0043525 IMP     positive regulation of neuron apoptotic process GO:0043525 ISO     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISS     development of secondary sexual characteristics GO:0045136 IMP     cellular respiration GO:0045333 ISO     retinal cell programmed cell death GO:0046666 IMP     positive regulation of developmental pigmentation GO:0048087 IGI     negative regulation of fibroblast proliferation GO:0048147 IMP     spermatid differentiation GO:0048515 IMP     post-embryonic camera-type eye morphogenesis GO:0048597 IGI     response to axon injury GO:0048678 IMP     homeostasis of number of cells GO:0048872 IGI     homeostasis of number of cells GO:0048872 IMP     homeostasis of number of cells within a tissue GO:0048873 IMP     epithelial cell proliferation GO:0050673 IDA     positive regulation of developmental process GO:0051094 IMP     protein insertion into mitochondrial membrane GO:0051204 IMP     release of sequestered calcium ion into cytosol GO:0051209 IMP     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP     neuron apoptotic process GO:0051402 IDA     neuron apoptotic process GO:0051402 IGI     neuron apoptotic process GO:0051402 IGI     neuron apoptotic process GO:0051402 IMP     neuron apoptotic process GO:0051402 IMP     establishment of localization in cell GO:0051649 IGI     establishment of localization in cell GO:0051649 IMP     regulation of cell cycle GO:0051726 IGI     regulation of mitochondrial membrane potential GO:0051881 IDA     regulation of mitochondrial membrane potential GO:0051881 ISO     Sertoli cell proliferation GO:0060011 IGI     retina development in camera-type eye GO:0060041 IMP     apoptotic process involved in mammary gland involution GO:0060057 IMP     positive regulation of apoptotic process involved in mammary gland involution GO:0060058 IMP     vagina development GO:0060068 IGI     calcium ion transport into cytosol GO:0060402 IGI     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IGI     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISO     thymocyte apoptotic process GO:0070242 IGI     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP     positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO     positive regulation of release of cytochrome c from mitochondria GO:0090200 ISS     motor neuron apoptotic process GO:0097049 IMP     motor neuron apoptotic process GO:0097049 IMP     apoptotic signaling pathway GO:0097190 IGI     apoptotic signaling pathway GO:0097190 IMP     apoptotic signaling pathway GO:0097190 ISO     extrinsic apoptotic signaling pathway GO:0097191 ISO     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IBA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IGI     intrinsic apoptotic signaling pathway GO:0097193 IMP     intrinsic apoptotic signaling pathway GO:0097193 ISO     execution phase of apoptosis GO:0097194 IEA     execution phase of apoptosis GO:0097194 ISO     supramolecular fiber organization GO:0097435 IEA     supramolecular fiber organization GO:0097435 ISO     cellular response to virus GO:0098586 IEA     cellular response to virus GO:0098586 ISO     positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 ISO     regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 IGI     positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 IGI     apoptotic process involved in blood vessel morphogenesis GO:1902262 IGI     apoptotic process involved in embryonic digit morphogenesis GO:1902263 IGI     regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 IMP     positive regulation of apoptotic DNA fragmentation GO:1902512 IEA     positive regulation of apoptotic DNA fragmentation GO:1902512 ISO     epithelial cell apoptotic process GO:1904019 IMP     positive regulation of epithelial cell apoptotic process GO:1904037 IMP     B cell receptor apoptotic signaling pathway GO:1990117 IEA     B cell receptor apoptotic signaling pathway GO:1990117 ISO     regulation of cysteine-type endopeptidase activity GO:2000116 IMP     positive regulation of reproductive process GO:2000243 IMP     positive regulation of motor neuron apoptotic process GO:2000673 IMP     positive regulation of cysteine-type endopeptidase activity GO:2001056 IDA     positive regulation of cysteine-type endopeptidase activity GO:2001056 IDA     positive regulation of cysteine-type endopeptidase activity GO:2001056 IGI     positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP     negative regulation of apoptotic signaling pathway GO:2001234 IGI     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS Subcellular Localization     intracellular anatomical structure GO:0005622 IDA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nuclear envelope GO:0005635 IEA     nuclear envelope GO:0005635 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IBA     mitochondrial outer membrane GO:0005741 IDA     mitochondrial outer membrane GO:0005741 ISO     mitochondrial permeability transition pore complex GO:0005757 ISO     mitochondrial permeability transition pore complex GO:0005757 ISS     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 ISO     endoplasmic reticulum membrane GO:0005789 ISS     cytosol GO:0005829 IDA     cytosol GO:0005829 ISO     membrane GO:0016020 ISS     mitochondrial membrane GO:0031966 IDA     mitochondrial membrane GO:0031966 ISO     pore complex GO:0046930 ISO     pore complex GO:0046930 ISS     perinuclear region of cytoplasm GO:0048471 ISO     cell periphery GO:0071944 IEA     cell periphery GO:0071944 ISO     Bcl-2 family protein complex GO:0097136 ISO     Bcl-2 family protein complex GO:0097136 ISS     BAX complex GO:0097144 IPI     BAX complex GO:0097144 ISO     BAX complex GO:0097144 ISS     BAK complex GO:0097145 IEA     BAK complex GO:0097145 ISO