Gene description for Ptges3
Gene name prostaglandin E synthase 3 (cytosolic)
Gene symbol Ptges3
Other names/aliases 5730442A20Rik
Ptges
Tebp
cPGES
p23
sid3177
Species Mus musculus
 Database cross references - Ptges3
ExoCarta ExoCarta_56351
Entrez Gene 56351
UniProt Q9R0Q7  
 Ptges3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptges3
Molecular Function
    isomerase activity GO:0016853 IEA
    unfolded protein binding GO:0051082 ISO
    prostaglandin-E synthase activity GO:0050220 ISO
    Hsp90 protein binding GO:0051879 ISO
    enzyme binding GO:0019899 ISO
    p53 binding GO:0002039 ISO
    telomerase activity GO:0003720 ISO
Biological Process
    RNA-dependent DNA replication GO:0006278 ISO
    fatty acid metabolic process GO:0006631 IEA
    prostaglandin metabolic process GO:0006693 ISO
    prostaglandin biosynthetic process GO:0001516 ISO
    lung saccule development GO:0060430 IMP
    cell proliferation GO:0008283 IMP
    glucocorticoid receptor signaling pathway GO:0042921 IMP
    lipid metabolic process GO:0006629 IEA
    chaperone cofactor-dependent protein refolding GO:0070389 ISO
    skin development GO:0043588 IMP
    fatty acid biosynthetic process GO:0006633 IEA
    DNA biosynthetic process GO:0071897 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of cell death GO:0060548 ISO
    glycogen biosynthetic process GO:0005978 IMP
    sensory perception of pain GO:0019233 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    neuronal cell body GO:0043025 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    nucleoplasm GO:0005654 ISO
    telomerase holoenzyme complex GO:0005697 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    protein complex GO:0043234 ISO
    cytoplasm GO:0005737 ISO
    actin filament GO:0005884 ISO
    neuron projection GO:0043005 ISO
 Experiment description of studies that identified Ptges3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptges3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptges3 is involved
PathwayEvidenceSource
Attenuation phase IEA Reactome
HSF1 activation IEA Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) IEA Reactome





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