Gene description for Ppid
Gene name peptidylprolyl isomerase D (cyclophilin D)
Gene symbol Ppid
Other names/aliases 4930564J03Rik
CYP-40
Ppidl
Ppif
Species Mus musculus
 Database cross references - Ppid
ExoCarta ExoCarta_67738
Vesiclepedia VP_67738
Entrez Gene 67738
UniProt Q9CR16  
 Ppid identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppid
Molecular Function
    isomerase activity GO:0016853 IEA
    heat shock protein binding GO:0031072 ISO
    Hsp90 protein binding GO:0051879 ISO
    cyclosporin A binding GO:0016018 ISO
    transcription factor binding GO:0008134 ISO
    peptide binding GO:0042277 IEA
    FK506 binding GO:0005528 TAS
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISS
    enzyme binding GO:0019899 ISO
Biological Process
    protein folding GO:0006457 IEA
    chaperone-mediated protein folding GO:0061077 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of protein secretion GO:0050714 ISO
    regulation of apoptotic process GO:0042981 IBA
    protein transport GO:0015031 IEA
    positive regulation of viral genome replication GO:0045070 ISO
    transport GO:0006810 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    protein complex assembly GO:0006461 ISO
    cellular response to UV-A GO:0071492 ISO
    lipid particle organization GO:0034389 ISO
    protein peptidyl-prolyl isomerization GO:0000413 ISS
    apoptotic process GO:0006915 IEA
Subcellular Localization
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ppid in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppid
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMURF2 64750
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml
 Pathways in which Ppid is involved
No pathways found





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