Gene description for Ppid
Gene name peptidylprolyl isomerase D (cyclophilin D)
Gene symbol Ppid
Other names/aliases 4930564J03Rik
CYP-40
Ppidl
Ppif
Species Mus musculus
 Database cross references - Ppid
ExoCarta ExoCarta_67738
Vesiclepedia VP_67738
Entrez Gene 67738
UniProt Q9CR16  
 Ppid identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppid
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISS
    FK506 binding GO:0005528 TAS
    transcription factor binding GO:0008134 ISO
    transcription factor binding GO:0008134 ISS
    cyclosporin A binding GO:0016018 IBA
    cyclosporin A binding GO:0016018 ISO
    enzyme binding GO:0019899 ISO
    nuclear estrogen receptor binding GO:0030331 ISS
    Hsp70 protein binding GO:0030544 ISS
    heat shock protein binding GO:0031072 ISO
    Hsp90 protein binding GO:0051879 ISO
    Hsp90 protein binding GO:0051879 ISS
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    protein peptidyl-prolyl isomerization GO:0000413 ISO
    protein folding GO:0006457 IBA
    protein folding GO:0006457 ISS
    apoptotic process GO:0006915 IEA
    protein transport GO:0015031 IEA
    lipid droplet organization GO:0034389 ISO
    lipid droplet organization GO:0034389 ISS
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISS
    positive regulation of viral genome replication GO:0045070 IEA
    positive regulation of viral genome replication GO:0045070 ISO
    positive regulation of protein secretion GO:0050714 IEA
    positive regulation of protein secretion GO:0050714 ISO
    chaperone-mediated protein folding GO:0061077 ISO
    chaperone-mediated protein folding GO:0061077 ISS
    protein-containing complex assembly GO:0065003 ISO
    protein-containing complex assembly GO:0065003 ISS
    cellular response to UV-A GO:0071492 ISO
    cellular response to UV-A GO:0071492 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    nucleolus GO:0005730 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ppid in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppid
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gpalpp1  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 SMURF2 64750
Affinity Capture-Luminescence Homo sapiens
4 Tfe3  
Affinity Capture-MS Mus musculus
5 Ptges3 56351
Co-fractionation Mus musculus
6 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Ppid is involved
No pathways found





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