|
 Gene description for Nt5c |
| Gene name |
5',3'-nucleotidase, cytosolic |
| Gene symbol |
Nt5c |
| Other names/aliases |
Dnt
Dnt1
Umph-2
Umph2 |
| Species |
Mus musculus |
| Database cross references - Nt5c |
| ExoCarta |
ExoCarta_50773 |
| Vesiclepedia |
VP_50773 |
| Entrez Gene |
50773 |
| UniProt |
Q9JM14
|
| Nt5c identified in exosomes derived from the following tissue/cell type |
|
Melanoma cells
|
34957415
|
|
Melanoma cells
|
34957415
|
| Gene ontology annotations for Nt5c |
| Molecular Function |
| |
phosphatase activity |
GO:0016791 |
IDA |
|
| |
MAP kinase tyrosine/serine/threonine phosphatase activity |
GO:0017017 |
IEA |
|
| |
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity |
GO:0052830 |
IEA |
|
| |
inositol bisphosphate phosphatase activity |
GO:0016312 |
IEA |
|
| |
phosphatidylinositol-4-phosphate phosphatase activity |
GO:0043812 |
IEA |
|
| |
inositol-1,3,4-trisphosphate 1-phosphatase activity |
GO:0052829 |
IEA |
|
| |
inositol-1,3,4-trisphosphate 4-phosphatase activity |
GO:0017161 |
IEA |
|
| |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
GO:0043813 |
IEA |
|
| |
protein tyrosine/threonine phosphatase activity |
GO:0008330 |
IEA |
|
| |
transmembrane receptor protein phosphatase activity |
GO:0019198 |
IEA |
|
| |
metal ion binding |
GO:0046872 |
IEA |
|
| |
inositol-3,4-bisphosphate 4-phosphatase activity |
GO:0052828 |
IEA |
|
| |
phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity |
GO:0052867 |
IEA |
|
| |
NADP phosphatase activity |
GO:0019178 |
IEA |
|
| |
protein tyrosine/serine/threonine phosphatase activity |
GO:0008138 |
IEA |
|
| |
nucleotidase activity |
GO:0008252 |
ISO |
|
| |
IDP phosphatase activity |
GO:1990003 |
IEA |
|
| |
pyrimidine nucleotide binding |
GO:0019103 |
ISO |
|
| |
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity |
GO:0030351 |
IEA |
|
| |
JUN kinase phosphatase activity |
GO:0008579 |
IEA |
|
| |
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity |
GO:0030352 |
IEA |
|
| |
hydrolase activity |
GO:0016787 |
IEA |
|
| |
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity |
GO:0052825 |
IEA |
|
| |
inositol-4,5-bisphosphate 5-phosphatase activity |
GO:0030487 |
IEA |
|
| |
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity |
GO:0043726 |
IEA |
|
| |
inositol phosphate phosphatase activity |
GO:0052745 |
IEA |
|
| |
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity |
GO:0052831 |
IEA |
|
| |
phosphohistidine phosphatase activity |
GO:0008969 |
IEA |
|
| |
nucleotide binding |
GO:0000166 |
IEA |
|
| |
5'-nucleotidase activity |
GO:0008253 |
ISO |
|
| |
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
GO:0052629 |
IEA |
|
| Biological Process |
| |
deoxyribonucleotide catabolic process |
GO:0009264 |
IDA |
|
| |
nucleotide metabolic process |
GO:0009117 |
IEA |
|
| |
pyrimidine deoxyribonucleotide catabolic process |
GO:0009223 |
ISO |
|
| |
dephosphorylation |
GO:0016311 |
ISO |
|
| Subcellular Localization |
| |
extracellular exosome |
GO:0070062 |
ISO |
|
| |
mitochondrion |
GO:0005739 |
IDA |
|
| |
cytoplasm |
GO:0005737 |
ISO |
|
| |
nucleus |
GO:0005634 |
ISO |
|
|
| Experiment description of studies that identified Nt5c in exosomes |
| 1 |
| Experiment ID |
1117 |
| MISEV standards |
|
✘
|
EV Biophysical techniques |
|
✔
Cd81|Icam1
|
EV Enriched markers |
|
✘
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
34957415
|
| Organism |
Mus musculus |
| Experiment description |
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism |
| Authors |
GarcÃa-Silva S, Benito-MartÃn A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÃ, Torres-Ruiz R, RodrÃguez-Perales S, MartÃnez L, Pérez-MartÃnez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, MartÃnez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, MegÃas D, Mehrara BJ, Lyden D, Peinado H. |
| Journal name |
Nat Cancer
|
| Publication year |
2021 |
| Sample |
Melanoma cells |
| Sample name |
B16-F1R2 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| 2 |
| Experiment ID |
1118 |
| MISEV standards |
|
✘
|
EV Biophysical techniques |
|
✔
Cd81|Icam1
|
EV Enriched markers |
|
✘
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
34957415
|
| Organism |
Mus musculus |
| Experiment description |
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism |
| Authors |
GarcÃa-Silva S, Benito-MartÃn A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÃ, Torres-Ruiz R, RodrÃguez-Perales S, MartÃnez L, Pérez-MartÃnez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, MartÃnez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, MegÃas D, Mehrara BJ, Lyden D, Peinado H. |
| Journal name |
Nat Cancer
|
| Publication year |
2021 |
| Sample |
Melanoma cells |
| Sample name |
B16-F1R2 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| Protein-protein interactions for Nt5c |
| |
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
|
No interactions are found.
|
|
| Pathways in which Nt5c is involved |
|
|
|
