Gene description for FAM8A1
Gene name family with sequence similarity 8, member A1
Gene symbol FAM8A1
Other names/aliases AHCP
Species Homo sapiens
 Database cross references - FAM8A1
ExoCarta ExoCarta_51439
Vesiclepedia VP_51439
Entrez Gene 51439
HGNC 16372
UniProt Q9UBU6  
 FAM8A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAM8A1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    ERAD pathway GO:0036503 IC
Subcellular Localization
    Hrd1p ubiquitin ligase complex GO:0000836 IDA
 Experiment description of studies that identified FAM8A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAM8A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTGIR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RHBDD1 84236
Affinity Capture-MS Homo sapiens
3 CD320 51293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TMEM9 252839
Affinity Capture-MS Homo sapiens
6 SLC18A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC51A  
Affinity Capture-MS Homo sapiens
8 SURF4 6836
Affinity Capture-MS Homo sapiens
9 RXFP1  
Affinity Capture-MS Homo sapiens
10 ZDHHC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PIP 5304
Affinity Capture-MS Homo sapiens
12 NDFIP2 54602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
14 ZDHHC12  
Affinity Capture-MS Homo sapiens
15 ATP13A2  
Two-hybrid Homo sapiens
16 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CHRNA1  
Affinity Capture-MS Homo sapiens
19 GOLT1B 51026
Affinity Capture-MS Homo sapiens
20 Rmdn3  
Affinity Capture-MS Mus musculus
21 P2RY2 5029
Affinity Capture-MS Homo sapiens
22 ATP1B4  
Affinity Capture-MS Homo sapiens
23 ERLEC1 27248
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
24 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PLSCR1 5359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 IL22RA2  
Affinity Capture-MS Homo sapiens
28 OSBPL8 114882
Affinity Capture-MS Homo sapiens
29 SYVN1 84447
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MBTPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 OS9 10956
Affinity Capture-MS Homo sapiens
32 P2RY8  
Affinity Capture-MS Homo sapiens
33 SDCBP 6386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LPAR1 1902
Affinity Capture-MS Homo sapiens
35 GCNT2 2651
Affinity Capture-MS Homo sapiens
36 COMTD1 118881
Affinity Capture-MS Homo sapiens
37 FUT3 2525
Affinity Capture-MS Homo sapiens
38 NDFIP1 80762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MS4A15  
Affinity Capture-MS Homo sapiens
41 C12orf49  
Affinity Capture-MS Homo sapiens
42 EGFL6 25975
Affinity Capture-MS Homo sapiens
43 NAAA  
Affinity Capture-MS Homo sapiens
44 OMA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CAPRIN2  
Affinity Capture-MS Homo sapiens
47 RAB9A 9367
Affinity Capture-MS Homo sapiens
48 SLC24A3  
Affinity Capture-MS Homo sapiens
49 PTCHD3  
Affinity Capture-MS Homo sapiens
50 FAM189A2  
Affinity Capture-MS Homo sapiens
51 CREB3  
Affinity Capture-MS Homo sapiens
52 SEL1L 6400
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
53 CLEC2B  
Affinity Capture-MS Homo sapiens
54 LY6G6D  
Affinity Capture-MS Homo sapiens
55 B4GALT3 8703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 VDAC3 7419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 LPPR2  
Affinity Capture-MS Homo sapiens
58 ABHD14A  
Affinity Capture-MS Homo sapiens
59 HIGD2A  
Affinity Capture-MS Homo sapiens
60 CLEC4E  
Affinity Capture-MS Homo sapiens
61 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 KCNE4  
Affinity Capture-MS Homo sapiens
63 SLC22A9  
Affinity Capture-MS Homo sapiens
64 ZACN  
Affinity Capture-MS Homo sapiens
65 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 GLG1 2734
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM8A1 is involved
No pathways found





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