Gene description for ERO1LB
Gene name ERO1-like beta (S. cerevisiae)
Gene symbol ERO1LB
Other names/aliases -
Species Homo sapiens
 Database cross references - ERO1LB
ExoCarta ExoCarta_56605
Vesiclepedia VP_56605
Entrez Gene 56605
HGNC 14355
MIM 615437
UniProt Q86YB8  
 ERO1LB identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ERO1LB
Molecular Function
    protein binding GO:0005515 IPI
    protein disulfide oxidoreductase activity GO:0015035 IEA
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 IEA
    oxidoreductase activity GO:0016491 NAS
    unfolded protein binding GO:0051082 NAS
    protein disulfide isomerase activity GO:0003756 IEA
Biological Process
    glucose homeostasis GO:0042593 IEA
    4-hydroxyproline metabolic process GO:0019471 IEA
    insulin processing GO:0030070 IEA
    protein maturation by protein folding GO:0022417 IEA
    oxidation-reduction process GO:0055114 IEA
    protein folding GO:0006457 TAS
    extracellular matrix organization GO:0030198 IEA
    cell redox homeostasis GO:0045454 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified ERO1LB in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ERO1LB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERP44 23071
Invivo Homo sapiens
2 P4HB 5034
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ERO1LB is involved
PathwayEvidenceSource
Insulin processing TAS Reactome





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