Gene description for PDIA2
Gene name protein disulfide isomerase family A, member 2
Gene symbol PDIA2
Other names/aliases PDA2
PDI
PDIP
PDIR
Species Homo sapiens
 Database cross references - PDIA2
ExoCarta ExoCarta_64714
Vesiclepedia VP_64714
Entrez Gene 64714
HGNC 14180
MIM 608012
UniProt Q13087  
 PDIA2 identified in exosomes derived from the following tissue/cell type
Glioma cells 19109410    
 Gene ontology annotations for PDIA2
Molecular Function
    protein disulfide isomerase activity GO:0003756 IBA
    protein disulfide isomerase activity GO:0003756 IEA
    steroid binding GO:0005496 IEA
    protein binding GO:0005515 IPI
    protein-disulfide reductase activity GO:0015035 IDA
    disulfide oxidoreductase activity GO:0015036 TAS
Biological Process
    protein folding GO:0006457 IBA
    protein retention in ER lumen GO:0006621 TAS
    protein folding in endoplasmic reticulum GO:0034975 TAS
    response to endoplasmic reticulum stress GO:0034976 IBA
    platelet aggregation GO:0070527 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 IEA
 Experiment description of studies that identified PDIA2 in exosomes
1
Experiment ID 28
MISEV standards
EM
Biophysical techniques
HSP70|HSC70
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Homo sapiens
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Glioma cells
Sample name X43,T
D456MG
H2159MG
D54MG
D247MG
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for PDIA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERO1LB 56605
Affinity Capture-Western Homo sapiens
2 HM13 81502
Affinity Capture-Western Homo sapiens
3 PPARG 5468
Reconstituted Complex Homo sapiens
4 P4HB 5034
Cross-Linking-MS (XL-MS) Homo sapiens
5 COL2A1 1280
Reconstituted Complex Homo sapiens
6 LRP1 4035
Affinity Capture-Western Homo sapiens
7 SST  
Reconstituted Complex Homo sapiens
8 TAP1 6890
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
9 P4HA3 283208
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 CUL3 8452
Two-hybrid Homo sapiens
11 ERO1L 30001
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 GAPDH 2597
Reconstituted Complex Homo sapiens
13 P4HTM  
Reconstituted Complex Homo sapiens
14 MTTP 4547
Affinity Capture-Western Homo sapiens
15 KRTAP6-1  
Two-hybrid Homo sapiens
16 CD3D 915
Affinity Capture-Western Homo sapiens
17 SYVN1 84447
Affinity Capture-Western Homo sapiens
18 KRTAP12-1  
Two-hybrid Homo sapiens
19 AMFR 267
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PDIA2 is involved
No pathways found





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