Gene description for PDIA2
Gene name protein disulfide isomerase family A, member 2
Gene symbol PDIA2
Other names/aliases PDA2
PDI
PDIP
PDIR
Species Homo sapiens
 Database cross references - PDIA2
ExoCarta ExoCarta_64714
Entrez Gene 64714
HGNC 14180
MIM 608012
UniProt Q13087  
 PDIA2 identified in exosomes derived from the following tissue/cell type
Glioma cells 19109410    
 Gene ontology annotations for PDIA2
Molecular Function
    protein binding GO:0005515 IPI
    steroid binding GO:0005496 IEA
    peptidyl-proline 4-dioxygenase activity GO:0031545 IBA
    protein disulfide isomerase activity GO:0003756 IEA
    disulfide oxidoreductase activity GO:0015036 TAS
Biological Process
    protein folding in endoplasmic reticulum GO:0034975 TAS
    peptidyl-proline hydroxylation GO:0019511 IBA
    protein folding GO:0006457 TAS
    oxidation-reduction process GO:0055114 TAS
    cell redox homeostasis GO:0045454 IEA
    response to endoplasmic reticulum stress GO:0034976 IBA
    protein retention in ER lumen GO:0006621 TAS
    regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902175 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum lumen GO:0005788 IEA
 Experiment description of studies that identified PDIA2 in exosomes
1
Experiment ID 28
ISEV standards
EM
EV Biophysical techniques
HSP70|HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Homo sapiens
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Glioma cells
Sample name X43,T
D456MG
H2159MG
D54MG
D247MG
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for PDIA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDIA2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here