Gene description for PEG3
Gene name paternally expressed 3
Gene symbol PEG3
Other names/aliases PW1
Species Homo sapiens
 Database cross references - PEG3
ExoCarta ExoCarta_5178
Entrez Gene 5178
HGNC 8826
MIM 601483
UniProt Q9GZU2  
 PEG3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PEG3
Molecular Function
    nucleic acid binding GO:0003676 IEA
    metal ion binding GO:0046872 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
Biological Process
    in utero embryonic development GO:0001701 IEA
    apoptotic process GO:0006915 IEA
    genetic imprinting GO:0071514 IEA
    multicellular organism growth GO:0035264 IEA
    transcription from RNA polymerase II promoter GO:0006366 IBA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified PEG3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PEG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 BRCA1 672
Far Western Homo sapiens
3 SIAH2 6478
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PEG3 is involved
No pathways found

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