Gene description for UNC13D
Gene name unc-13 homolog D (C. elegans)
Gene symbol UNC13D
Other names/aliases FHL3
HLH3
HPLH3
Munc13-4
Species Homo sapiens
 Database cross references - UNC13D
ExoCarta ExoCarta_201294
Entrez Gene 201294
HGNC 23147
MIM 608897
UniProt Q70J99  
 UNC13D identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for UNC13D
Molecular Function
    Rab GTPase binding GO:0017137 IPI
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of exocytosis GO:0045921 IMP
    regulation of mast cell degranulation GO:0043304 IMP
    phagocytosis GO:0006909 IEA
    positive regulation of regulated secretory pathway GO:1903307 IGI
    natural killer cell degranulation GO:0043320 IEA
    defense response to virus GO:0051607 IEA
    germinal center formation GO:0002467 IEA
    granuloma formation GO:0002432 IEA
Subcellular Localization
    late endosome GO:0005770 IEA
    membrane GO:0016020 IEA
    exocytic vesicle GO:0070382 IDA
    lysosome GO:0005764 IDA
    Weibel-Palade body GO:0033093 IDA
    recycling endosome GO:0055037 IEA
 Experiment description of studies that identified UNC13D in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UNC13D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB27A 5873
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which UNC13D is involved
No pathways found





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