Gene description for AACS
Gene name acetoacetyl-CoA synthetase
Gene symbol AACS
Other names/aliases ACSF1
SUR-5
Species Homo sapiens
 Database cross references - AACS
ExoCarta ExoCarta_65985
Entrez Gene 65985
HGNC 21298
MIM 614364
UniProt Q86V21  
 AACS identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for AACS
Molecular Function
    acetoacetate-CoA ligase activity GO:0030729 IEA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    butyrate-CoA ligase activity GO:0047760 IEA
Biological Process
    white fat cell differentiation GO:0050872 IEA
    response to ethanol GO:0045471 IEA
    positive regulation of insulin secretion GO:0032024 IEA
    response to drug GO:0042493 IEA
    adipose tissue development GO:0060612 IEA
    response to starvation GO:0042594 IEA
    response to purine-containing compound GO:0014074 IEA
    fatty acid metabolic process GO:0006631 IEA
    response to oleic acid GO:0034201 IEA
    liver development GO:0001889 IEA
    cellular response to glucose stimulus GO:0071333 IEA
    cellular response to testosterone stimulus GO:0071394 IEA
    cellular response to cholesterol GO:0071397 IEA
    response to nutrient GO:0007584 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
 Experiment description of studies that identified AACS in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AACS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AACS is involved
No pathways found





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