Gene description for MEP1B
Gene name meprin A, beta
Gene symbol MEP1B
Other names/aliases -
Species Homo sapiens
 Database cross references - MEP1B
ExoCarta ExoCarta_4225
Entrez Gene 4225
HGNC 7020
MIM 600389
UniProt Q16820  
 MEP1B identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 25890246    
 Gene ontology annotations for MEP1B
Molecular Function
    zinc ion binding GO:0008270 IEA
    metalloendopeptidase activity GO:0004222 IEA
    protein binding GO:0005515 IPI
Biological Process
    inflammatory response GO:0006954 IEA
    digestion GO:0007586 TAS
    proteolysis GO:0006508 IEA
    toxin transport GO:1901998 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    extracellular space GO:0005615 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified MEP1B in exosomes
1
Experiment ID 283
ISEV standards
CEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81|EpCAM
EV Membrane markers
EV Negative markers
DLS
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for MEP1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invitro Homo sapiens
2 GAS  
Biochemical Activity Homo sapiens
3 PYY  
Biochemical Activity Homo sapiens
4 MEP1A 4224
Invitro Homo sapiens
5 MEP1B 4225
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MEP1B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here