Gene description for NDNL2
Gene name necdin-like 2
Gene symbol NDNL2
Other names/aliases HCA4
MAGEG1
MAGEL3
NSE3
NSMCE3
Species Homo sapiens
 Database cross references - NDNL2
ExoCarta ExoCarta_56160
Entrez Gene 56160
HGNC 7677
MIM 608243
UniProt Q96MG7  
 NDNL2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for NDNL2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    protein sumoylation GO:0016925 TAS
    DNA recombination GO:0006310 IEA
    post-translational protein modification GO:0043687 TAS
    DNA repair GO:0006281 IEA
    positive regulation of protein ubiquitination GO:0031398 IDA
    regulation of growth GO:0040008 IEA
Subcellular Localization
    chromosome, telomeric region GO:0000781 IEA
    cytoplasm GO:0005737 IEA
    Smc5-Smc6 complex GO:0030915 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified NDNL2 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NDNL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NGFR 4804
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 E2F1 1869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which NDNL2 is involved
PathwayEvidenceSource
SUMOylation of DNA damage response and repair proteins TAS Reactome





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