Gene description for Il6st
Gene name	interleukin 6 signal transducer
Gene symbol	Il6st
Other names/aliases	5133400A03Rik AA389424 BB405851 CD130 D13Ertd699e gp130
Species	Mus musculus
Database cross references - Il6st
ExoCarta	ExoCarta_16195
Vesiclepedia	VP_16195
Entrez Gene	16195
UniProt	Q00560
Il6st identified in exosomes derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Il6st

Molecular Function     growth factor binding GO:0019838 ISO     oncostatin-M receptor activity GO:0004924 ISO     interleukin-11 binding GO:0019970 IDA     protein binding GO:0005515 IPI     ciliary neurotrophic factor receptor binding GO:0005127 ISO     interleukin-6 receptor activity GO:0004915 ISO     leukemia inhibitory factor receptor activity GO:0004923 ISO     interleukin-11 receptor activity GO:0004921 IDA     protein heterodimerization activity GO:0046982 ISO     interleukin-6 receptor binding GO:0005138 ISO     cytokine receptor activity GO:0004896 IEA     interleukin-6 binding GO:0019981 ISO     ciliary neurotrophic factor receptor activity GO:0004897 ISO Biological Process     cytokine-mediated signaling pathway GO:0019221 ISO     signal transduction GO:0007165 IDA     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of astrocyte differentiation GO:0048711 IMP     negative regulation of interleukin-6-mediated signaling pathway GO:0070104 ISO     leukemia inhibitory factor signaling pathway GO:0048861 ISO     ciliary neurotrophic factor-mediated signaling pathway GO:0070120 ISO     regulation of Notch signaling pathway GO:0008593 IDA     interleukin-27-mediated signaling pathway GO:0070106 ISO     positive regulation of cell proliferation GO:0008284 ISO     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 ISO     response to cytokine GO:0034097 ISO     negative regulation of cytosolic calcium ion concentration GO:0051481 ISO     interleukin-6-mediated signaling pathway GO:0070102 ISO     positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 ISO     triglyceride mobilization GO:0006642 ISO     oncostatin-M-mediated signaling pathway GO:0038165 ISO     positive regulation of smooth muscle cell migration GO:0014911 ISO     positive regulation of osteoblast differentiation GO:0045669 ISO     glycogen metabolic process GO:0005977 IMP Subcellular Localization     ciliary neurotrophic factor receptor complex GO:0070110 ISO     oncostatin-M receptor complex GO:0005900 ISO     neuronal cell body GO:0043025 IDA     integral component of membrane GO:0016021 IEA     cytosol GO:0005829 ISO     interleukin-6 receptor complex GO:0005896 ISO     extracellular exosome GO:0070062 ISO     external side of plasma membrane GO:0009897 IDA     dendrite GO:0030425 IDA     extracellular space GO:0005615 ISO     membrane GO:0016020 ISO     cell body GO:0044297 IDA     neuronal cell body membrane GO:0032809 ISO