Gene description for Sla2
Gene name Src-like-adaptor 2
Gene symbol Sla2
Other names/aliases A930009E21Rik
AI430952
SLAP-2
SLAP2
Species Mus musculus
 Database cross references - Sla2
ExoCarta ExoCarta_77799
Vesiclepedia VP_77799
Entrez Gene 77799
UniProt Q8R4L0  
 Sla2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sla2
Molecular Function
    protein binding GO:0005515 IPI
    protein binding GO:0005515 ISS
    protein-macromolecule adaptor activity GO:0030674 ISS
    signaling adaptor activity GO:0035591 IBA
    signaling adaptor activity GO:0035591 ISO
    signaling adaptor activity GO:0035591 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    adaptive immune response GO:0002250 IEA
    T cell activation GO:0042110 IDA
    T cell activation GO:0042110 ISO
    negative regulation of calcium-mediated signaling GO:0050849 IEA
    negative regulation of calcium-mediated signaling GO:0050849 ISO
    negative regulation of T cell receptor signaling pathway GO:0050860 IEA
    negative regulation of T cell receptor signaling pathway GO:0050860 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IDA
    cytoplasmic vesicle GO:0031410 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Sla2 in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sla2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cbl 12402
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Zap70 22637
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Sla2 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system IEA Reactome
FLT3 Signaling IEA Reactome
Immune System IEA Reactome
Negative regulation of FLT3 IEA Reactome





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