Gene description for Sla2
Gene name Src-like-adaptor 2
Gene symbol Sla2
Other names/aliases A930009E21Rik
AI430952
SLAP-2
SLAP2
Species Mus musculus
 Database cross references - Sla2
ExoCarta ExoCarta_77799
Vesiclepedia VP_77799
Entrez Gene 77799
UniProt Q8R4L0  
 Sla2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sla2
Molecular Function
    protein binding GO:0005515 IPI
    SH3/SH2 adaptor activity GO:0005070 ISS
    protein N-terminus binding GO:0047485 ISO
Biological Process
    positive regulation of signal transduction GO:0009967 ISS
    T cell activation GO:0042110 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    immune system process GO:0002376 IEA
    negative regulation of calcium-mediated signaling GO:0050849 ISO
Subcellular Localization
    late endosome GO:0005770 IDA
    membrane GO:0016020 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    cytoplasm GO:0005737 IEA
    cytoplasmic vesicle GO:0031410 IEA
    plasma membrane GO:0005886 IDA
    endosome GO:0005768 IEA
 Experiment description of studies that identified Sla2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sla2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sla2 is involved
No pathways found





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