Gene description for Lyn
Gene name	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene symbol	Lyn
Other names/aliases	AA407514 Hck-2 p53Lyn p56Lyn
Species	Mus musculus
Database cross references - Lyn
ExoCarta	ExoCarta_17096
Entrez Gene	17096
UniProt	P25911
Lyn identified in exosomes derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846
Mast cells	17486113

Gene ontology annotations for Lyn

Molecular Function     receptor binding GO:0005102 ISO     protein complex binding GO:0032403 ISO     glycosphingolipid binding GO:0043208 ISO     ion channel binding GO:0044325 ISO     protein binding GO:0005515 IPI     gamma-tubulin binding GO:0043015 ISO     enzyme binding GO:0019899 ISO     erythropoietin receptor binding GO:0005128 TAS     transferase activity GO:0016740 IEA     kinase activity GO:0016301 IEA     nucleotide binding GO:0000166 IEA     platelet-derived growth factor receptor binding GO:0005161 ISO     SH3 domain binding GO:0017124 IPI     ubiquitin protein ligase binding GO:0031625 ISO     phosphoprotein binding GO:0051219 ISO     protein kinase activity GO:0004672 IDA     protein tyrosine kinase activity GO:0004713 ISO     ATP binding GO:0005524 IEA     integrin binding GO:0005178 ISO     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     transferase activity, transferring phosphorus-containing groups GO:0016772 IEA Biological Process     negative regulation of MAP kinase activity GO:0043407 IMP     immune response-regulating cell surface receptor signaling pathway GO:0002768 IMP     phosphorylation GO:0016310 IEA     regulation of B cell receptor signaling pathway GO:0050855 IMP     protein autophosphorylation GO:0046777 TAS     negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP     innate immune response GO:0045087 IBA     negative regulation of intracellular signal transduction GO:1902532 IMP     erythrocyte differentiation GO:0030218 IMP     positive regulation of cell migration GO:0030335 IMP     negative regulation of B cell proliferation GO:0030889 IMP     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     positive regulation of cell proliferation GO:0008284 IMP     regulation of ERK1 and ERK2 cascade GO:0070372 IMP     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO     negative regulation of cell proliferation GO:0008285 ISO     positive regulation of B cell receptor signaling pathway GO:0050861 IGI     regulation of cytokine secretion GO:0050707 IMP     regulation of B cell apoptotic process GO:0002902 IMP     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     negative regulation of mast cell proliferation GO:0070667 IMP     regulation of platelet aggregation GO:0090330 IMP     lipopolysaccharide-mediated signaling pathway GO:0031663 IMP     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP     response to hormone GO:0009725 IDA     positive regulation of dendritic cell apoptotic process GO:2000670 IMP     cellular response to DNA damage stimulus GO:0006974 ISO     regulation of inflammatory response GO:0050727 IMP     positive regulation of phosphorylation GO:0042327 ISO     Fc receptor mediated stimulatory signaling pathway GO:0002431 IMP     regulation of mast cell degranulation GO:0043304 IMP     regulation of cytokine production GO:0001817 IMP     cytokine secretion GO:0050663 ISO     positive regulation of cellular component movement GO:0051272 ISO     regulation of mast cell activation GO:0033003 IMP     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IMP     B cell receptor signaling pathway GO:0050853 IDA     hemoglobin biosynthetic process GO:0042541 TAS     positive regulation of neuron projection development GO:0010976 ISO     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 IMP     negative regulation of myeloid leukocyte differentiation GO:0002762 IMP     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 ISO     positive regulation of stress-activated protein kinase signaling cascade GO:0070304 ISO     tolerance induction to self antigen GO:0002513 IMP     regulation of erythrocyte differentiation GO:0045646 IMP     negative regulation of protein phosphorylation GO:0001933 IMP     intracellular signal transduction GO:0035556 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IMP     positive regulation of mast cell proliferation GO:0070668 ISO     platelet degranulation GO:0002576 IMP     neuron projection development GO:0031175 IMP     dendritic cell differentiation GO:0097028 IMP     peptidyl-tyrosine phosphorylation GO:0018108 ISO     cellular response to peptide hormone stimulus GO:0071375 IBA     hemopoiesis GO:0030097 IMP     protein phosphorylation GO:0006468 ISO     regulation of cell adhesion mediated by integrin GO:0033628 ISO     signal transduction GO:0007165 TAS     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 ISO     histamine secretion by mast cell GO:0002553 ISO     Fc receptor mediated inhibitory signaling pathway GO:0002774 IMP     immune system process GO:0002376 IEA     cellular response to retinoic acid GO:0071300 ISO     inflammatory response GO:0006954 IEA     positive regulation of glial cell proliferation GO:0060252 ISO     regulation of monocyte chemotaxis GO:0090025 ISO     B cell homeostasis GO:0001782 IMP Subcellular Localization     integrin alpha2-beta1 complex GO:0034666 ISO     cell-cell adherens junction GO:0005913 ISO     nucleus GO:0005634 ISO     mitochondrial intermembrane space GO:0005758 ISO     postsynaptic density GO:0014069 ISO     membrane raft GO:0045121 ISO     mitochondrial membrane GO:0031966 ISO     perinuclear region of cytoplasm GO:0048471 ISO     extracellular exosome GO:0070062 ISO     mast cell granule GO:0042629 ISO     mitochondrial crista GO:0030061 ISO     cell GO:0005623 IMP     Golgi apparatus GO:0005794 ISO     cytoplasm GO:0005737 IDA     membrane GO:0016020 ISO     plasma membrane GO:0005886 ISO     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA