Gene description for Khdrbs1
Gene name KH domain containing, RNA binding, signal transduction associated 1
Gene symbol Khdrbs1
Other names/aliases Sam68
p62
p68
Species Mus musculus
 Database cross references - Khdrbs1
ExoCarta ExoCarta_20218
Vesiclepedia VP_20218
Entrez Gene 20218
UniProt Q60749  
 Khdrbs1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Khdrbs1
Molecular Function
    nucleic acid binding GO:0003676 IEA
    poly(U) RNA binding GO:0008266 ISO
    RNA binding GO:0003723 ISO
    SH3/SH2 adaptor activity GO:0005070 ISO
    poly(A) RNA binding GO:0044822 ISO
    protein binding GO:0005515 IPI
    poly(A) binding GO:0008143 ISO
    SH3 domain binding GO:0017124 ISO
    protein complex binding GO:0032403 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    positive regulation of signal transduction GO:0009967 IPI
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of translational initiation GO:0045948 ISO
    positive regulation of RNA export from nucleus GO:0046833 ISO
    regulation of RNA export from nucleus GO:0046831 IDA
    cell surface receptor signaling pathway GO:0007166 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    cell cycle GO:0007049 IEA
Subcellular Localization
    membrane GO:0016020 ISO
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
    Grb2-Sos complex GO:0070618 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Khdrbs1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Khdrbs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Khdrbs1 is involved
No pathways found





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