Gene description for Hnrnpl
Gene name heterogeneous nuclear ribonucleoprotein L
Gene symbol Hnrnpl
Other names/aliases C79783
D830027H13Rik
Hnrpl
Species Mus musculus
 Database cross references - Hnrnpl
ExoCarta ExoCarta_15388
Vesiclepedia VP_15388
Entrez Gene 15388
UniProt Q8R081  
 Hnrnpl identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hnrnpl
Molecular Function
    nucleotide binding GO:0000166 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    mRNA 3'-UTR binding GO:0003730 ISO
    RNA binding GO:0003723 IEA
    nucleic acid binding GO:0003676 IEA
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    mRNA processing GO:0006397 IEA
    positive regulation of mRNA binding GO:1902416 ISO
    positive regulation of translation GO:0045727 ISO
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO
    cellular response to amino acid starvation GO:0034198 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    ribonucleoprotein complex GO:0030529 ISO
    pronucleus GO:0045120 IDA
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Hnrnpl in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hnrnpl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hnrnpl is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here