Gene description for MICAL3
Gene name microtubule associated monooxygenase, calponin and LIM domain containing 3
Gene symbol MICAL3
Other names/aliases MICAL-3
Species Homo sapiens
 Database cross references - MICAL3
ExoCarta ExoCarta_57553
Entrez Gene 57553
HGNC 24694
MIM 608882
UniProt Q7RTP6  
 MICAL3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MICAL3
Molecular Function
    actin binding GO:0003779 ISS
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 ISS
    zinc ion binding GO:0008270 IEA
    FAD binding GO:0071949 ISS
    Rab GTPase binding GO:0017137 IEA
Biological Process
    actin filament depolymerization GO:0030042 ISS
    cytoskeleton organization GO:0007010 IDA
    oxidation-reduction process GO:0055114 ISS
    exocytosis GO:0006887 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified MICAL3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MICAL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MICAL3 is involved
No pathways found





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