Gene description for RHBDD3
Gene name rhomboid domain containing 3
Gene symbol RHBDD3
Other names/aliases C22orf3
HS984G1A
PTAG
Species Homo sapiens
 Database cross references - RHBDD3
ExoCarta ExoCarta_25807
Vesiclepedia VP_25807
Entrez Gene 25807
HGNC 1308
UniProt Q9Y3P4  
 RHBDD3 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RHBDD3
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
Biological Process
    MAPK cascade GO:0000165 IEA
    liver development GO:0001889 IEA
    regulation of acute inflammatory response GO:0002673 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    negative regulation of natural killer cell activation GO:0032815 IEA
    positive regulation of protein catabolic process GO:0045732 IEA
    regulation of protein secretion GO:0050708 IEA
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified RHBDD3 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RHBDD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FAM189B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC17A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 WBP2 23558
Two-hybrid Homo sapiens
6 SLC18A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 VAPB 9217
Affinity Capture-MS Homo sapiens
8 KCNC3 3748
Affinity Capture-MS Homo sapiens
9 BSCL2  
Affinity Capture-MS Homo sapiens
10 HSD3B7 80270
Proximity Label-MS Homo sapiens
11 UBC 7316
Affinity Capture-MS Homo sapiens
12 ARF4 378
Proximity Label-MS Homo sapiens
13 FNDC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 B3GAT1  
Proximity Label-MS Homo sapiens
15 CHRNB4  
Affinity Capture-MS Homo sapiens
16 RAB7A 7879
Proximity Label-MS Homo sapiens
17 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 IL27RA 9466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PTGFR 5737
Affinity Capture-MS Homo sapiens
21 TMEM31  
Affinity Capture-MS Homo sapiens
22 LRRC8B  
Affinity Capture-MS Homo sapiens
23 KCNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 POPDC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RHBDD3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here