Gene description for KCNC3
Gene name potassium channel, voltage gated Shaw related subfamily C, member 3
Gene symbol KCNC3
Other names/aliases KSHIIID
KV3.3
SCA13
Species Homo sapiens
 Database cross references - KCNC3
ExoCarta ExoCarta_3748
Entrez Gene 3748
HGNC 6235
MIM 176264
UniProt Q14003  
 KCNC3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCNC3
Molecular Function
    voltage-gated potassium channel activity GO:0005249 TAS
    delayed rectifier potassium channel activity GO:0005251 IBA
Biological Process
    regulation of ion transmembrane transport GO:0034765 IEA
    synaptic transmission GO:0007268 TAS
    protein homooligomerization GO:0051260 IEA
    regulation of neurotransmitter secretion GO:0046928 IEA
    potassium ion transport GO:0006813 TAS
    potassium ion transmembrane transport GO:0071805 IBA
Subcellular Localization
    integral component of membrane GO:0016021 IBA
    axon terminus GO:0043679 IEA
    voltage-gated potassium channel complex GO:0008076 IEA
    axolemma GO:0030673 IEA
    neuromuscular junction GO:0031594 IEA
    plasma membrane GO:0005886 TAS
    dendrite membrane GO:0032590 IEA
    neuronal cell body membrane GO:0032809 IEA
 Experiment description of studies that identified KCNC3 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KCNC3 is involved
PathwayEvidenceSource
Voltage gated Potassium channels TAS Reactome





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