Gene description for KCNC3
Gene name potassium channel, voltage gated Shaw related subfamily C, member 3
Gene symbol KCNC3
Other names/aliases KSHIIID
KV3.3
SCA13
Species Homo sapiens
 Database cross references - KCNC3
ExoCarta ExoCarta_3748
Vesiclepedia VP_3748
Entrez Gene 3748
HGNC 6235
MIM 176264
UniProt Q14003  
 KCNC3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCNC3
Molecular Function
    voltage-gated potassium channel activity GO:0005249 IDA
    voltage-gated potassium channel activity GO:0005249 IMP
    voltage-gated potassium channel activity GO:0005249 ISS
    delayed rectifier potassium channel activity GO:0005251 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    action potential GO:0001508 IBA
    potassium ion transport GO:0006813 IDA
    cortical actin cytoskeleton organization GO:0030866 IDA
    protein homooligomerization GO:0051260 IEA
    protein tetramerization GO:0051262 IDA
    potassium ion transmembrane transport GO:0071805 IBA
    potassium ion transmembrane transport GO:0071805 IMP
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell cortex GO:0005938 IDA
    voltage-gated potassium channel complex GO:0008076 IBA
    voltage-gated potassium channel complex GO:0008076 IDA
    dendrite GO:0030425 IDA
    dendrite membrane GO:0032590 IBA
    dendritic spine membrane GO:0032591 IEA
    neuronal cell body membrane GO:0032809 IBA
    presynaptic membrane GO:0042734 IBA
    perikaryon GO:0043204 IEA
    axon terminus GO:0043679 IBA
    postsynaptic membrane GO:0045211 IBA
 Experiment description of studies that identified KCNC3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCNC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 PAX6  
Affinity Capture-MS Homo sapiens
4 FGFR1 2260
Affinity Capture-MS Homo sapiens
5 PLEKHH3  
Affinity Capture-MS Homo sapiens
6 PTPRD 5789
Affinity Capture-MS Homo sapiens
7 ATF6  
Affinity Capture-MS Homo sapiens
8 AXL 558
Affinity Capture-MS Homo sapiens
9 NDFIP1 80762
Affinity Capture-MS Homo sapiens
10 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
11 KCNC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TNS1 7145
Affinity Capture-MS Homo sapiens
13 P4HA1 5033
Affinity Capture-MS Homo sapiens
14 EPHX1 2052
Affinity Capture-MS Homo sapiens
15 BMPR1A 657
Affinity Capture-MS Homo sapiens
16 RHBDD3 25807
Affinity Capture-MS Homo sapiens
17 SLC12A2 6558
Affinity Capture-MS Homo sapiens
18 KDELR1 10945
Affinity Capture-MS Homo sapiens
19 ATF6B  
Affinity Capture-MS Homo sapiens
20 SLC20A1 6574
Affinity Capture-MS Homo sapiens
21 FYN 2534
Affinity Capture-MS Homo sapiens
22 JAK1 3716
Affinity Capture-MS Homo sapiens
23 DDR1 780
Affinity Capture-MS Homo sapiens
24 C17orf70  
Affinity Capture-MS Homo sapiens
25 VRK2 7444
Affinity Capture-MS Homo sapiens
26 OSMR 9180
Affinity Capture-MS Homo sapiens
27 PCNXL3 399909
Affinity Capture-MS Homo sapiens
28 KCNC1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCNC3 is involved
PathwayEvidenceSource
Neuronal System TAS Reactome
Potassium Channels TAS Reactome
Voltage gated Potassium channels TAS Reactome





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