Gene description for AP1G2
Gene name adaptor-related protein complex 1, gamma 2 subunit
Gene symbol AP1G2
Other names/aliases G2AD
Species Homo sapiens
 Database cross references - AP1G2
ExoCarta ExoCarta_8906
Entrez Gene 8906
HGNC 556
MIM 603534
UniProt O75843  
 AP1G2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AP1G2
Molecular Function
    protein binding GO:0005515 IPI
    protein transporter activity GO:0008565 IEA
Biological Process
    intracellular protein transport GO:0006886 IEA
    viral process GO:0016032 IEA
    vesicle-mediated transport GO:0016192 NAS
    membrane organization GO:0061024 TAS
    post-Golgi vesicle-mediated transport GO:0006892 TAS
Subcellular Localization
    Golgi-associated vesicle GO:0005798 IDA
    Golgi apparatus GO:0005794 TAS
    Golgi membrane GO:0000139 TAS
    AP-1 adaptor complex GO:0030121 TAS
    membrane GO:0016020 IDA
    endosome membrane GO:0010008 IEA
    transport vesicle GO:0030133 IDA
 Experiment description of studies that identified AP1G2 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AP1G2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP1S1 1174
Two-hybrid Homo sapiens
2 SYNRG 11276
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 XRN1 54464
Two-hybrid Homo sapiens
4 RAB5A 5868
Two-hybrid Homo sapiens
5 AP1S2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AP1G2 is involved
PathwayEvidenceSource
Lysosome Vesicle Biogenesis TAS Reactome





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