Gene description for AP1G2
Gene name adaptor-related protein complex 1, gamma 2 subunit
Gene symbol AP1G2
Other names/aliases G2AD
Species Homo sapiens
 Database cross references - AP1G2
ExoCarta ExoCarta_8906
Vesiclepedia VP_8906
Entrez Gene 8906
HGNC 556
MIM 603534
UniProt O75843  
 AP1G2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AP1G2
Molecular Function
    protein binding GO:0005515 IPI
    clathrin adaptor activity GO:0035615 IBA
Biological Process
    intracellular protein transport GO:0006886 IEA
    Golgi to vacuole transport GO:0006896 IBA
    vesicle-mediated transport GO:0016192 NAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 TAS
    Golgi-associated vesicle GO:0005798 IDA
    endosome membrane GO:0010008 IEA
    membrane GO:0016020 IDA
    AP-1 adaptor complex GO:0030121 IBA
    AP-1 adaptor complex GO:0030121 TAS
    transport vesicle GO:0030133 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified AP1G2 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AP1G2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNRG 11276
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PIGU 128869
Affinity Capture-MS Homo sapiens
3 AP2B1 163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 IFNLR1  
Affinity Capture-MS Homo sapiens
5 AP1M1 8907
Co-fractionation Homo sapiens
6 NEDD4 4734
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
7 ATG2B 55102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TMX3 54495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 UPK3B  
Affinity Capture-MS Homo sapiens
11 AP1S2 8905
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ATXN1L  
Two-hybrid Homo sapiens
13 CENPK  
Two-hybrid Homo sapiens
14 FAM96A  
Affinity Capture-MS Homo sapiens
15 HDHD1  
Affinity Capture-MS Homo sapiens
16 SYNE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PRMT6  
Two-hybrid Homo sapiens
18 UBR7  
Co-fractionation Homo sapiens
19 EGFR 1956
Affinity Capture-MS Homo sapiens
20 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
21 METTL21B  
Affinity Capture-MS Homo sapiens
22 PPP4R1L  
Affinity Capture-MS Homo sapiens
23 XRN1 54464
Two-hybrid Homo sapiens
24 IL27RA 9466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 THBS2 7058
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 AP1S3  
Affinity Capture-MS Homo sapiens
28 APEX1 328
Affinity Capture-RNA Homo sapiens
29 CRYBB3  
Affinity Capture-MS Homo sapiens
30 AAGAB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 KDM1A 23028
Two-hybrid Homo sapiens
32 IST1 9798
Co-fractionation Homo sapiens
33 INF2 64423
Affinity Capture-MS Homo sapiens
34 C12orf74  
Affinity Capture-MS Homo sapiens
35 RBM3 5935
Affinity Capture-MS Homo sapiens
36 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PIGT 51604
Affinity Capture-MS Homo sapiens
38 D2HGDH 728294
Affinity Capture-MS Homo sapiens
39 SSSCA1 10534
Affinity Capture-MS Homo sapiens
40 KIF5B 3799
Co-fractionation Homo sapiens
41 AP1G1 164
Co-fractionation Homo sapiens
42 AP1M2 10053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
43 CHIA  
Affinity Capture-MS Homo sapiens
44 RNF13 11342
Affinity Capture-MS Homo sapiens
45 PIGS 94005
Affinity Capture-MS Homo sapiens
46 ALB 213
Affinity Capture-MS Homo sapiens
47 GPAA1 8733
Affinity Capture-MS Homo sapiens
48 ZNF318 24149
Affinity Capture-MS Homo sapiens
49 ZYG11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SF3B3 23450
Affinity Capture-MS Homo sapiens
51 AP1S1 1174
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
52 SDHAP2  
Affinity Capture-MS Homo sapiens
53 COMT 1312
Affinity Capture-MS Homo sapiens
54 AP1B1 162
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
55 ATG7 10533
Affinity Capture-MS Homo sapiens
56 HYPM  
Affinity Capture-MS Homo sapiens
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