Gene description for SAMD4A
Gene name sterile alpha motif domain containing 4A
Gene symbol SAMD4A
Other names/aliases SAMD4
SMAUG
SMAUG1
SMG
SMGA
Species Homo sapiens
 Database cross references - SAMD4A
ExoCarta ExoCarta_23034
Entrez Gene 23034
HGNC 23023
MIM 610747
UniProt Q9UPU9  
 SAMD4A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SAMD4A
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    translation repressor activity GO:0030371 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of translation GO:0045727 IDA
    negative regulation of translation GO:0017148 IDA
Subcellular Localization
    synapse GO:0045202 IEA
    cytoplasm GO:0005737 IEA
    cell junction GO:0030054 IEA
    dendrite GO:0030425 IEA
 Experiment description of studies that identified SAMD4A in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SAMD4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SAMD4A is involved
No pathways found





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