Gene description for TCN1
Gene name transcobalamin I (vitamin B12 binding protein, R binder family)
Gene symbol TCN1
Other names/aliases HC
TC-1
TC1
TCI
Species Homo sapiens
 Database cross references - TCN1
ExoCarta ExoCarta_6947
Entrez Gene 6947
HGNC 11652
MIM 189905
UniProt P20061  
 TCN1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TCN1
Molecular Function
    cobalamin binding GO:0031419 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    cobalamin transport GO:0015889 IEA
    cobalt ion transport GO:0006824 IEA
    vitamin metabolic process GO:0006766 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    cobalamin metabolic process GO:0009235 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified TCN1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TCN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TCN1 is involved
PathwayEvidenceSource
Cobalamin (Cbl, vitamin B12) transport and metabolism TAS Reactome





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