Gene description for Pdgfra
Gene name platelet derived growth factor receptor, alpha polypeptide
Gene symbol Pdgfra
Other names/aliases AI115593
Species Mus musculus
 Database cross references - Pdgfra
ExoCarta ExoCarta_18595
Entrez Gene 18595
UniProt P26618  
 Pdgfra identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Pdgfra
Molecular Function
    vascular endothelial growth factor binding GO:0038085 ISO
    protein complex binding GO:0032403 IDA
    vascular endothelial growth factor-activated receptor activity GO:0005021 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    protein homodimerization activity GO:0042803 ISO
    transferase activity GO:0016740 IEA
    nucleotide binding GO:0000166 IEA
    protein kinase activity GO:0004672 ISO
    platelet-derived growth factor receptor binding GO:0005161 ISO
    protein tyrosine kinase activity GO:0004713 IEA
    platelet-derived growth factor binding GO:0048407 TAS
    transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO
    ATP binding GO:0005524 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 ISO
    kinase activity GO:0016301 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
Biological Process
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IMP
    positive regulation of phospholipase C activity GO:0010863 ISO
    organ morphogenesis GO:0009887 IMP
    phosphorylation GO:0016310 IEA
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO
    embryonic cranial skeleton morphogenesis GO:0048701 IMP
    skeletal system morphogenesis GO:0048705 IMP
    cardiac myofibril assembly GO:0055003 IGI
    multicellular organismal development GO:0007275 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    retina vasculature development in camera-type eye GO:0061298 IGI
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    cellular response to amino acid stimulus GO:0071230 IDA
    positive regulation of cell migration GO:0030335 ISO
    face morphogenesis GO:0060325 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    signal transduction involved in regulation of gene expression GO:0023019 IDA
    Leydig cell differentiation GO:0033327 IMP
    negative regulation of platelet activation GO:0010544 ISO
    positive regulation of fibroblast proliferation GO:0048146 ISO
    in utero embryonic development GO:0001701 IMP
    platelet aggregation GO:0070527 ISO
    odontogenesis of dentin-containing tooth GO:0042475 IMP
    regulation of chemotaxis GO:0050920 ISO
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISO
    regulation of mesenchymal stem cell differentiation GO:2000739 ISO
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    cell migration GO:0016477 IMP
    male genitalia development GO:0030539 IMP
    wound healing GO:0042060 IMP
    positive regulation of DNA replication GO:0045740 ISO
    cellular response to platelet-derived growth factor stimulus GO:0036120 ISO
    extracellular matrix organization GO:0030198 IMP
    positive regulation of cell proliferation GO:0008284 ISO
    metanephric glomerular capillary formation GO:0072277 IGI
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 ISO
    embryonic digestive tract morphogenesis GO:0048557 IMP
    palate development GO:0060021 IMP
    cell chemotaxis GO:0060326 ISO
    lung development GO:0030324 IMP
    female gonad development GO:0008585 IGI
    cellular response to reactive oxygen species GO:0034614 ISO
    estrogen metabolic process GO:0008210 IGI
    chemotaxis GO:0006935 IEA
    protein autophosphorylation GO:0046777 ISO
    anatomical structure morphogenesis GO:0009653 IMP
    protein phosphorylation GO:0006468 IEA
    phosphatidylinositol-mediated signaling GO:0048015 ISO
    luteinization GO:0001553 IMP
    adrenal gland development GO:0030325 IGI
Subcellular Localization
    plasma membrane GO:0005886 ISO
    microvillus GO:0005902 IDA
    cytosol GO:0005829 ISO
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    integral component of membrane GO:0016021 IEA
    protein complex GO:0043234 ISO
    integral component of plasma membrane GO:0005887 ISO
    cytoplasm GO:0005737 ISO
    intrinsic component of plasma membrane GO:0031226 ISO
    nucleus GO:0005634 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Pdgfra in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pdgfra
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdgfra is involved
Downstream signal transduction IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Signaling by PDGF IEA Reactome

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