Gene description for MECOM
Gene name	MDS1 and EVI1 complex locus
Gene symbol	MECOM
Other names/aliases	AML1-EVI-1 EVI1 MDS1 MDS1-EVI1 PRDM3
Species	Homo sapiens
Database cross references - MECOM
ExoCarta	ExoCarta_2122
Entrez Gene	2122
HGNC	3498
MIM	165215
UniProt	Q03112   Q13465
MECOM identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for MECOM

Molecular Function     protein homodimerization activity GO:0042803 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     DNA binding GO:0003677 ISS Biological Process     renal system development GO:0072001 IEA     inflammatory response GO:0006954 IEA     cell differentiation GO:0030154 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     in utero embryonic development GO:0001701 IEA     forebrain development GO:0030900 IEA     negative regulation of programmed cell death GO:0043069 IMP     hematopoietic stem cell proliferation GO:0071425 ISS     negative regulation of JNK cascade GO:0046329 IMP     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA     response to bacterium GO:0009617 IEA     regulation of cell cycle GO:0051726 IDA     transcription, DNA-templated GO:0006351 IEA     pericardium development GO:0060039 IEA     regulation of transcription, DNA-templated GO:0006355 TAS     apoptotic process GO:0006915 IEA     neutrophil homeostasis GO:0001780 IEA     negative regulation of transcription, DNA-templated GO:0045892 IDA     positive regulation of transcription, DNA-templated GO:0045893 IDA     chromatin organization GO:0006325 TAS     regulation of cell proliferation GO:0042127 IEA     post-embryonic development GO:0009791 IEA     embryonic forelimb morphogenesis GO:0035115 IEA     embryonic hindlimb morphogenesis GO:0035116 IEA Subcellular Localization     aggresome GO:0016235 IDA     Golgi apparatus GO:0005794 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 IDA     nucleus GO:0005634 IDA     nuclear speck GO:0016607 IDA     cytoplasm GO:0005737 IDA     histone deacetylase complex GO:0000118 IDA