Gene description for MYBPC2
Gene name myosin binding protein C, fast type
Gene symbol MYBPC2
Other names/aliases MYBPC
MYBPCF
Species Homo sapiens
 Database cross references - MYBPC2
ExoCarta ExoCarta_4606
Entrez Gene 4606
HGNC 7550
MIM 160793
UniProt Q14324  
 MYBPC2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for MYBPC2
Molecular Function
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
    structural constituent of muscle GO:0008307 TAS
Biological Process
    muscle filament sliding GO:0030049 TAS
    cell adhesion GO:0007155 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    myosin filament GO:0032982 IEA
 Experiment description of studies that identified MYBPC2 in exosomes
1
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for MYBPC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MYBPC2 is involved
PathwayEvidenceSource
Striated Muscle Contraction TAS Reactome





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