Gene description for TNNI2
Gene name troponin I type 2 (skeletal, fast)
Gene symbol TNNI2
Other names/aliases AMCD2B
DA2B
FSSV
fsTnI
Species Homo sapiens
 Database cross references - TNNI2
ExoCarta ExoCarta_7136
Vesiclepedia VP_7136
Entrez Gene 7136
HGNC 11946
MIM 191043
UniProt P48788  
 TNNI2 identified in sEVs derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for TNNI2
Molecular Function
    actin binding GO:0003779 IDA
    protein binding GO:0005515 IPI
    troponin T binding GO:0031014 IPI
Biological Process
    skeletal muscle contraction GO:0003009 IBA
    skeletal muscle contraction GO:0003009 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    cardiac muscle contraction GO:0060048 IBA
    relaxation of skeletal muscle GO:0090076 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    troponin complex GO:0005861 IBA
    troponin complex GO:0005861 IDA
 Experiment description of studies that identified TNNI2 in sEVs
1
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TNNI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUCB2 4925
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MNS1 55329
Two-hybrid Homo sapiens
3 CTNNA3  
Two-hybrid Homo sapiens
4 UBE2M 9040
Affinity Capture-MS Homo sapiens
5 LIMCH1 22998
Affinity Capture-MS Homo sapiens
6 TLE1 7088
Affinity Capture-MS Homo sapiens
7 DCAF11  
Two-hybrid Homo sapiens
8 TRIM55  
Two-hybrid Homo sapiens
9 SIRT1  
Affinity Capture-MS Homo sapiens
10 EFCAB2  
Two-hybrid Homo sapiens
11 LATS1  
Affinity Capture-MS Homo sapiens
12 TLE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TNNC1  
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
14 ESRRA  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 NME7 29922
Two-hybrid Homo sapiens
16 C1orf109  
Two-hybrid Homo sapiens
17 ESRRG  
Two-hybrid Homo sapiens
18 HNF4G  
Two-hybrid Homo sapiens
19 MECOM 2122
Affinity Capture-MS Homo sapiens
20 RORB  
Two-hybrid Homo sapiens
21 UPF2 26019
Two-hybrid Homo sapiens
22 KLHL21 9903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TRIM63  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 RFTN2 130132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TNNT1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TNNI2 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Striated Muscle Contraction TAS Reactome





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