Gene description for TNNI2
Gene name troponin I type 2 (skeletal, fast)
Gene symbol TNNI2
Other names/aliases AMCD2B
DA2B
FSSV
fsTnI
Species Homo sapiens
 Database cross references - TNNI2
ExoCarta ExoCarta_7136
Entrez Gene 7136
HGNC 11946
MIM 191043
UniProt P48788  
 TNNI2 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for TNNI2
Molecular Function
    actin binding GO:0003779 IDA
    troponin T binding GO:0031014 IPI
    protein binding GO:0005515 IPI
Biological Process
    muscle filament sliding GO:0030049 TAS
    skeletal muscle contraction GO:0003009 IDA
    regulation of muscle contraction GO:0006937 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    troponin complex GO:0005861 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TNNI2 in exosomes
1
Experiment ID 196
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TNNI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNNC1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TNNI2 is involved
PathwayEvidenceSource
Striated Muscle Contraction TAS Reactome





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