Gene description for MNS1
Gene name meiosis-specific nuclear structural 1
Gene symbol MNS1
Other names/aliases SPATA40
Species Homo sapiens
 Database cross references - MNS1
ExoCarta ExoCarta_55329
Vesiclepedia VP_55329
Entrez Gene 55329
HGNC 29636
MIM 610766
UniProt Q8NEH6  
 MNS1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MNS1
Molecular Function
    identical protein binding GO:0042802 IDA
Biological Process
    cilium organization GO:0044782 IEA
    left/right axis specification GO:0070986 IEA
    meiotic cell cycle GO:0051321 IEA
Subcellular Localization
    nuclear envelope GO:0005635 IEA
    sperm flagellum GO:0036126 IEA
    axoneme GO:0005930 IEA
    intermediate filament GO:0005882 IEA
 Experiment description of studies that identified MNS1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MNS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MNS1 is involved
No pathways found





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