Gene description for TNNI1
Gene name troponin I type 1 (skeletal, slow)
Gene symbol TNNI1
Other names/aliases SSTNI
TNN1
Species Homo sapiens
 Database cross references - TNNI1
ExoCarta ExoCarta_7135
Vesiclepedia VP_7135
Entrez Gene 7135
HGNC 11945
MIM 191042
UniProt P19237  
 TNNI1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TNNI1
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
Biological Process
    skeletal muscle contraction GO:0003009 IBA
    regulation of striated muscle contraction GO:0006942 NAS
    transition between fast and slow fiber GO:0014883 IEA
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IEA
    cardiac muscle contraction GO:0060048 IBA
Subcellular Localization
    cytosol GO:0005829 TAS
    troponin complex GO:0005861 IBA
 Experiment description of studies that identified TNNI1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TNNI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Two-hybrid Homo sapiens
2 MNS1 55329
Two-hybrid Homo sapiens
3 ENKD1  
Two-hybrid Homo sapiens
4 CABP2  
Two-hybrid Homo sapiens
5 CTNNA3  
Two-hybrid Homo sapiens
6 TNNT1  
Two-hybrid Homo sapiens
7 PKD2L1  
Reconstituted Complex Homo sapiens
8 C2orf68  
Two-hybrid Homo sapiens
9 KIFC3 3801
Two-hybrid Homo sapiens
10 SCNM1  
Two-hybrid Homo sapiens
11 TPM2 7169
Co-fractionation Homo sapiens
12 POLR1C 9533
Two-hybrid Homo sapiens
13 TRIM41 90933
Two-hybrid Homo sapiens
14 EIF1AD 84285
Two-hybrid Homo sapiens
15 TNNT2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 PIH1D2  
Two-hybrid Homo sapiens
17 MDFI  
Two-hybrid Homo sapiens
18 CETN3  
Two-hybrid Homo sapiens
19 DCAF11  
Two-hybrid Homo sapiens
20 TRIM55  
Two-hybrid Homo sapiens
21 PNMA1 9240
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CCDC102B  
Two-hybrid Homo sapiens
23 EFCAB2  
Two-hybrid Homo sapiens
24 ARMC7  
Two-hybrid Homo sapiens
25 CDCA7L  
Two-hybrid Homo sapiens
26 CEP19  
Two-hybrid Homo sapiens
27 TNNC1  
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 TPM1 7168
Co-fractionation Homo sapiens
29 CCDC57 284001
Two-hybrid Homo sapiens
30 MYH6 4624
Co-fractionation Homo sapiens
31 EAF1  
Two-hybrid Homo sapiens
32 CCDC85B  
Two-hybrid Homo sapiens
33 TRIM63  
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
34 ESRRG  
Two-hybrid Homo sapiens
35 ANKRD11 29123
Two-hybrid Homo sapiens
36 EIF3B 8662
Two-hybrid Homo sapiens
37 SYCE1L  
Two-hybrid Homo sapiens
38 ACTN2 88
Co-fractionation Homo sapiens
39 MYH7 4625
Co-fractionation Homo sapiens
40 PRKAB2 5565
Two-hybrid Homo sapiens
41 SPANXN2  
Two-hybrid Homo sapiens
42 MYH3 4621
Co-fractionation Homo sapiens
43 MTUS2 23281
Two-hybrid Homo sapiens
44 SAT1  
Two-hybrid Homo sapiens
45 CABP5  
Two-hybrid Homo sapiens
46 USP20  
Two-hybrid Homo sapiens
47 TPM3 7170
Two-hybrid Homo sapiens
48 PIK3R3 8503
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TNNI1 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Striated Muscle Contraction TAS Reactome





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