Gene description for MYH8
Gene name myosin, heavy chain 8, skeletal muscle, perinatal
Gene symbol MYH8
Other names/aliases DA7
MyHC-peri
MyHC-pn
gtMHC-F
Species Homo sapiens
 Database cross references - MYH8
ExoCarta ExoCarta_4626
Entrez Gene 4626
HGNC 7578
MIM 160741
UniProt P13535  
 MYH8 identified in exosomes derived from the following tissue/cell type
Malignant pleural effusions 14975938    
 Gene ontology annotations for MYH8
Molecular Function
    actin filament binding GO:0051015 TAS
    calmodulin binding GO:0005516 IEA
    myosin light chain binding GO:0032027 TAS
    ATP binding GO:0005524 IMP
    ATPase activity GO:0016887 IMP
    structural constituent of muscle GO:0008307 NAS
    microfilament motor activity GO:0000146 IMP
Biological Process
    ATP metabolic process GO:0046034 IMP
    muscle contraction GO:0006936 NAS
    skeletal muscle contraction GO:0003009 IMP
    muscle filament sliding GO:0030049 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    muscle myosin complex GO:0005859 NAS
    myosin filament GO:0032982 IC
    sarcomere GO:0030017 IC
 Experiment description of studies that identified MYH8 in exosomes
1
Experiment ID 51
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90
EV Cytosolic markers
✔
MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for MYH8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MYH8 is involved
PathwayEvidenceSource
Striated Muscle Contraction TAS Reactome
Translocation of GLUT4 to the plasma membrane TAS Reactome





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