Gene description for MYH8
Gene name myosin, heavy chain 8, skeletal muscle, perinatal
Gene symbol MYH8
Other names/aliases DA7
MyHC-peri
MyHC-pn
gtMHC-F
Species Homo sapiens
 Database cross references - MYH8
ExoCarta ExoCarta_4626
Vesiclepedia VP_4626
Entrez Gene 4626
HGNC 7578
MIM 160741
UniProt P13535  
 MYH8 identified in exosomes derived from the following tissue/cell type
Malignant pleural effusions 14975938    
 Gene ontology annotations for MYH8
Molecular Function
    microfilament motor activity GO:0000146 IBA
    microfilament motor activity GO:0000146 IMP
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IMP
    structural constituent of muscle GO:0008307 NAS
    ATP hydrolysis activity GO:0016887 IMP
    myosin phosphatase activity GO:0017018 TAS
    myosin light chain binding GO:0032027 TAS
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 TAS
Biological Process
    skeletal muscle contraction GO:0003009 IMP
    muscle contraction GO:0006936 IBA
    muscle contraction GO:0006936 NAS
    muscle filament sliding GO:0030049 IMP
    muscle filament sliding GO:0030049 TAS
    ATP metabolic process GO:0046034 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    muscle myosin complex GO:0005859 NAS
    myosin II complex GO:0016460 IBA
    sarcomere GO:0030017 IC
    myosin filament GO:0032982 IBA
    myosin filament GO:0032982 IC
 Experiment description of studies that identified MYH8 in exosomes
1
Experiment ID 51
MISEV standards
EM
Biophysical techniques
HSP90|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for MYH8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 ROGDI 79641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LZTR1 8216
Affinity Capture-MS Homo sapiens
4 MYH13 8735
Affinity Capture-MS Homo sapiens
5 SUGP1  
Affinity Capture-MS Homo sapiens
6 LRRC59 55379
Cross-Linking-MS (XL-MS) Homo sapiens
7 TLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 AURKC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
10 TSPAN33 340348
Affinity Capture-MS Homo sapiens
11 FKBP6  
Affinity Capture-MS Homo sapiens
12 HDAC1 3065
Affinity Capture-MS Homo sapiens
13 SBDS 51119
Cross-Linking-MS (XL-MS) Homo sapiens
14 LATS1  
Affinity Capture-MS Homo sapiens
15 SHD  
Affinity Capture-MS Homo sapiens
16 SLC39A3  
Affinity Capture-MS Homo sapiens
17 GBA 2629
Affinity Capture-MS Homo sapiens
18 RSPH6A  
Affinity Capture-MS Homo sapiens
19 TPM1 7168
Co-fractionation Homo sapiens
20 ZSCAN5A  
Affinity Capture-MS Homo sapiens
21 ABTB2 25841
Affinity Capture-MS Homo sapiens
22 CCDC69 26112
Affinity Capture-MS Homo sapiens
23 ACTN2 88
Co-fractionation Homo sapiens
24 MCM2 4171
Affinity Capture-MS Homo sapiens
25 STYX  
Affinity Capture-MS Homo sapiens
26 LDLR 3949
Negative Genetic Homo sapiens
27 KRT40  
Affinity Capture-MS Homo sapiens
28 KRAS 3845
Synthetic Lethality Homo sapiens
29 LHPP 64077
Affinity Capture-MS Homo sapiens
30 MECOM 2122
Affinity Capture-MS Homo sapiens
31 PRKAR1B  
Affinity Capture-MS Homo sapiens
32 DNAJC12  
Affinity Capture-MS Homo sapiens
33 C2orf44  
Cross-Linking-MS (XL-MS) Homo sapiens
34 MYH4  
Affinity Capture-MS Homo sapiens
35 C1orf189  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYH8 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Striated Muscle Contraction TAS Reactome





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