Gene description for BCAS3
Gene name breast carcinoma amplified sequence 3
Gene symbol BCAS3
Other names/aliases GAOB1
MAAB
Species Homo sapiens
 Database cross references - BCAS3
ExoCarta ExoCarta_54828
Vesiclepedia VP_54828
Entrez Gene 54828
HGNC 14347
MIM 607470
UniProt Q9H6U6  
 BCAS3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BCAS3
Molecular Function
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    acetyltransferase activator activity GO:0010698 IDA
    nuclear receptor binding GO:0016922 IPI
    histone acetyltransferase binding GO:0035035 IPI
    phosphatidylinositol binding GO:0035091 IDA
    histone binding GO:0042393 IDA
    beta-tubulin binding GO:0048487 IDA
Biological Process
    angiogenesis GO:0001525 IEA
    autophagy GO:0006914 IEA
    cell-cell signaling GO:0007267 ISS
    positive regulation of endothelial cell migration GO:0010595 ISS
    regulation of actin cytoskeleton organization GO:0032956 ISS
    response to starvation GO:0042594 IBA
    positive regulation of catalytic activity GO:0043085 IDA
    response to estrogen GO:0043627 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    cellular response to estrogen stimulus GO:0071391 IDA
Subcellular Localization
    phagophore assembly site GO:0000407 IDA
    euchromatin GO:0000791 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasmic microtubule GO:0005881 ISS
    cell leading edge GO:0031252 ISS
    intermediate filament cytoskeleton GO:0045111 ISS
 Experiment description of studies that identified BCAS3 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCAS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD14 929
Affinity Capture-MS Homo sapiens
2 IL17RA 23765
Affinity Capture-MS Homo sapiens
3 PPM1M  
Affinity Capture-MS Homo sapiens
4 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 DOCK5 80005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 CTBP2 1488
Two-hybrid Homo sapiens
8 DNAJA2 10294
Affinity Capture-MS Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 ZDHHC17 23390
Two-hybrid Homo sapiens
11 KAT2B  
Affinity Capture-Western Homo sapiens
12 POLR3H  
Affinity Capture-MS Homo sapiens
13 MMP26  
Affinity Capture-MS Homo sapiens
14 PLEKHF2 79666
Two-hybrid Homo sapiens
15 SQSTM1 8878
Proximity Label-MS Homo sapiens
16 CDC23 8697
Two-hybrid Homo sapiens
17 HDAC1 3065
Affinity Capture-MS Homo sapiens
18 CAPZB 832
Affinity Capture-MS Homo sapiens
19 VWA5A 4013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MAGEE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 C22orf15  
Affinity Capture-MS Homo sapiens
24 C12orf74  
Affinity Capture-MS Homo sapiens
25 RAB2B 84932
Affinity Capture-MS Homo sapiens
26 CTBP1 1487
Two-hybrid Homo sapiens
27 WIPI2 26100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 WIPI1 55062
Affinity Capture-MS Homo sapiens
29 CELA2B  
Affinity Capture-MS Homo sapiens
30 PELP1 27043
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 RPA3 6119
Proximity Label-MS Homo sapiens
32 Wipi2 74781
Affinity Capture-MS Mus musculus
33 IRF3 3661
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCAS3 is involved
No pathways found





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