Gene description for ACY3
Gene name aminoacylase 3
Gene symbol ACY3
Other names/aliases ACY-3
HCBP1
Species Homo sapiens
 Database cross references - ACY3
ExoCarta ExoCarta_91703
Entrez Gene 91703
HGNC 24104
MIM 614413
UniProt Q96HD9  
 ACY3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ACY3
Molecular Function
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
    hydrolase activity, acting on ester bonds GO:0016788 IEA
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    aminoacylase activity GO:0004046 ISS
Biological Process
    biological_process GO:0008150 ND
    small molecule metabolic process GO:0044281 TAS
    viral process GO:0016032 IEA
    xenobiotic metabolic process GO:0006805 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified ACY3 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ACY3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACY3 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification TAS Reactome





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