Gene description for MARS2
Gene name methionyl-tRNA synthetase 2, mitochondrial
Gene symbol MARS2
Other names/aliases MetRS
mtMetRS
Species Homo sapiens
 Database cross references - MARS2
ExoCarta ExoCarta_92935
Vesiclepedia VP_92935
Entrez Gene 92935
HGNC 25133
MIM 609728
UniProt Q96GW9  
 MARS2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MARS2
Molecular Function
    ATP binding GO:0005524 IEA
    methionine-tRNA ligase activity GO:0004825 IDA
Biological Process
    tRNA aminoacylation for protein translation GO:0006418 TAS
    gene expression GO:0010467 TAS
    methionyl-tRNA aminoacylation GO:0006431 IDA
Subcellular Localization
    cytosol GO:0005829 IBA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified MARS2 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MARS2 is involved
PathwayEvidenceSource
Mitochondrial tRNA aminoacylation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here