Gene description for Rab22a
Gene name RAB22A, member RAS oncogene family
Gene symbol Rab22a
Other names/aliases 3732413A17Rik
AI662177
AW319644
AW550514
E130120E14Rik
Rab22
Species Mus musculus
 Database cross references - Rab22a
ExoCarta ExoCarta_19334
Vesiclepedia VP_19334
Entrez Gene 19334
UniProt P35285  
 Rab22a identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Embryonic fibroblasts 18494037    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rab22a
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 ISO
    GTP binding GO:0005525 ISO
    GDP binding GO:0019003 ISO
Biological Process
    Rab protein signal transduction GO:0032482 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    intracellular protein transport GO:0006886 IBA
    regulation of vesicle size GO:0097494 ISO
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
    endocytosis GO:0006897 ISO
    metabolic process GO:0008152 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    actin cytoskeleton GO:0015629 IDA
    phagocytic vesicle GO:0045335 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasmic vesicle GO:0031410 IEA
    cell projection GO:0042995 IEA
    endosome GO:0005768 IEA
    early endosome GO:0005769 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Rab22a in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 73
MISEV standards
EM
EV Biophysical techniques
HSP70|HSP90
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rab22a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMURF2 64750
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml
 Pathways in which Rab22a is involved
No pathways found





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