Gene description for MYLK2
Gene name myosin light chain kinase 2
Gene symbol MYLK2
Other names/aliases KMLC
MLCK
MLCK2
skMLCK
Species Homo sapiens
 Database cross references - MYLK2
ExoCarta ExoCarta_85366
Entrez Gene 85366
HGNC 16243
MIM 606566
UniProt Q9H1R3  
 MYLK2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MYLK2
Molecular Function
    myosin light chain kinase activity GO:0004687 ISS
    calmodulin binding GO:0005516 ISS
    calmodulin-dependent protein kinase activity GO:0004683 ISS
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
Biological Process
    protein autophosphorylation GO:0046777 IDA
    cardiac muscle tissue morphogenesis GO:0055008 IMP
    cardiac muscle contraction GO:0060048 IC
    skeletal muscle satellite cell differentiation GO:0014816 IEA
    neuromuscular synaptic transmission GO:0007274 IEA
    striated muscle contraction GO:0006941 IDA
    positive regulation of gene expression GO:0010628 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    regulation of muscle filament sliding GO:0032971 IDA
    skeletal muscle cell differentiation GO:0035914 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    sarcomere GO:0030017 IC
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified MYLK2 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYLK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MYLK2 is involved
No pathways found





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