Gene description for Rras2
Gene name related RAS viral (r-ras) oncogene homolog 2
Gene symbol Rras2
Other names/aliases 2610016H24Rik
C86394
TC21
Species Mus musculus
 Database cross references - Rras2
ExoCarta ExoCarta_66922
Vesiclepedia VP_66922
Entrez Gene 66922
UniProt P62071  
 Rras2 identified in sEVs derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Rras2
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
    GDP binding GO:0019003 IBA
    membrane scission GTPase motor activity GO:1990606 IEA
Biological Process
    Ras protein signal transduction GO:0007265 IDA
    Ras protein signal transduction GO:0007265 ISO
    cell migration GO:0016477 IGI
    Schwann cell migration GO:0036135 IGI
    positive regulation of Schwann cell migration GO:1900149 IGI
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    intracellular anatomical structure GO:0005622 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Rras2 in sEVs
1
Experiment ID 73
MISEV standards
EM
Biophysical techniques
HSP70|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors "Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ"
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Rras2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR1 90
Affinity Capture-Luminescence Homo sapiens
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 SMURF2 64750
Affinity Capture-Luminescence Homo sapiens
5 SMAD4  
Affinity Capture-Luminescence Homo sapiens
6 BMPR1B 658
Affinity Capture-Luminescence Homo sapiens
7 SMAD3 4088
Affinity Capture-Luminescence Homo sapiens
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