Gene description for ITGB1BP1
Gene name integrin beta 1 binding protein 1
Gene symbol ITGB1BP1
Other names/aliases ICAP-1A
ICAP-1B
ICAP-1alpha
ICAP1
ICAP1A
ICAP1B
Species Homo sapiens
 Database cross references - ITGB1BP1
ExoCarta ExoCarta_9270
Vesiclepedia VP_9270
Entrez Gene 9270
HGNC 23927
MIM 607153
UniProt O14713  
 ITGB1BP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ITGB1BP1
Molecular Function
    GDP-dissociation inhibitor activity GO:0005092 IDA
    integrin binding GO:0005178 IPI
    protein complex binding GO:0032403 IDA
    protein transporter activity GO:0008565 IDA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
Biological Process
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 IDA
    tube formation GO:0035148 IDA
    integrin-mediated signaling pathway GO:0007229 IDA
    negative regulation of protein kinase activity GO:0006469 IDA
    biomineral tissue development GO:0031214 IEA
    negative regulation of protein targeting to membrane GO:0090315 IDA
    integrin activation GO:0033622 ISS
    positive regulation of Notch signaling pathway GO:0045747 IDA
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    positive regulation of cell division GO:0051781 IEA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA
    negative regulation of protein binding GO:0032091 IDA
    negative regulation of focal adhesion assembly GO:0051895 IDA
    negative regulation of fibroblast migration GO:0010764 ISS
    regulation of GTPase activity GO:0043087 IDA
    positive regulation of cell proliferation GO:0008284 IDA
    myoblast migration GO:0051451 ISS
    negative regulation of cell proliferation GO:0008285 IDA
    cell differentiation GO:0030154 IEA
    positive regulation of stress fiber assembly GO:0051496 ISS
    positive regulation of protein kinase B signaling GO:0051897 IDA
    protein transport GO:0015031 IDA
    cell migration GO:0016477 TAS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of endothelial cell migration GO:0010595 IDA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    positive regulation of focal adhesion assembly GO:0051894 IEA
    regulation of blood vessel size GO:0050880 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    receptor clustering GO:0043113 ISS
    activation of protein kinase B activity GO:0032148 IDA
    intracellular signal transduction GO:0035556 TAS
    regulation of integrin-mediated signaling pathway GO:2001044 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    Notch signaling pathway GO:0007219 IEA
    cell-matrix adhesion GO:0007160 IDA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IDA
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 ISS
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA
    regulation of cell adhesion mediated by integrin GO:0033628 ISS
Subcellular Localization
    ruffle GO:0001726 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 IDA
    lamellipodium GO:0030027 IDA
    extracellular exosome GO:0070062 IDA
    cytoskeleton GO:0005856 ISS
    cell periphery GO:0071944 IDA
    nucleus GO:0005634 IDA
    focal adhesion GO:0005925 IDA
    membrane GO:0016020 NAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified ITGB1BP1 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ITGB1BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 LRP1 4035
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 TANK 10010
Affinity Capture-Western Homo sapiens
4 KRIT1 889
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 LRP8 7804
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ITGB1BP1 is involved
No pathways found





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