Gene description for INHBB
Gene name inhibin, beta B
Gene symbol INHBB
Other names/aliases -
Species Homo sapiens
 Database cross references - INHBB
ExoCarta ExoCarta_3625
Entrez Gene 3625
HGNC 6067
MIM 147390
UniProt P09529  
 INHBB identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for INHBB
Molecular Function
    hormone activity GO:0005179 TAS
    protein binding GO:0005515 IPI
    cytokine activity GO:0005125 TAS
    growth factor activity GO:0008083 IEA
    host cell surface receptor binding GO:0046789 TAS
    protein homodimerization activity GO:0042803 IPI
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    cell differentiation GO:0030154 NAS
    negative regulation of insulin secretion GO:0046676 ISS
    fat cell differentiation GO:0045444 ISS
    regulation of apoptotic process GO:0042981 IBA
    activin receptor signaling pathway GO:0032924 IDA
    cellular response to starvation GO:0009267 ISS
    negative regulation of hepatocyte growth factor biosynthetic process GO:0048178 IDA
    ovarian follicle development GO:0001541 NAS
    positive regulation of ovulation GO:0060279 ISS
    SMAD protein signal transduction GO:0060395 IBA
    response to mechanical stimulus GO:0009612 IDA
    cellular response to leptin stimulus GO:0044320 IEA
    cellular response to insulin stimulus GO:0032869 ISS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    cell development GO:0048468 IBA
    defense response GO:0006952 TAS
    growth GO:0040007 IEA
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
    positive regulation of follicle-stimulating hormone secretion GO:0046881 IPI
    regulation of MAPK cascade GO:0043408 IBA
    oocyte development GO:0048599 IEA
    negative regulation of follicle-stimulating hormone secretion GO:0046882 IPI
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular region GO:0005576 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified INHBB in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for INHBB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR2B  
Affinity Capture-Western Homo sapiens
2 ACVR2A  
Affinity Capture-Western Homo sapiens
3 ACVR1B 91
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which INHBB is involved
PathwayEvidenceSource
Antagonism of Activin by Follistatin TAS Reactome
Glycoprotein hormones TAS Reactome
Signaling by Activin TAS Reactome





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