Gene description for DHRS2
Gene name dehydrogenase/reductase (SDR family) member 2
Gene symbol DHRS2
Other names/aliases HEP27
SDR25C1
Species Homo sapiens
 Database cross references - DHRS2
ExoCarta ExoCarta_10202
Vesiclepedia VP_10202
Entrez Gene 10202
HGNC 18349
MIM 615194
UniProt Q13268  
 DHRS2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DHRS2
Molecular Function
    carbonyl reductase (NADPH) activity GO:0004090 IBA
    carbonyl reductase (NADPH) activity GO:0004090 IDA
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IDA
Biological Process
    C21-steroid hormone metabolic process GO:0008207 NAS
    negative regulation of cell population proliferation GO:0008285 NAS
    response to toxic substance GO:0009636 IDA
    electron transport chain GO:0022900 IDA
    cellular response to oxidative stress GO:0034599 IDA
    myeloid dendritic cell differentiation GO:0043011 IEP
    negative regulation of apoptotic process GO:0043066 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear envelope GO:0005635 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified DHRS2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DHRS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SDC4 6385
Affinity Capture-MS Homo sapiens
3 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ACSF2 80221
Affinity Capture-MS Homo sapiens
5 PREPL 9581
Affinity Capture-MS Homo sapiens
6 Ercc6l  
Affinity Capture-MS Mus musculus
7 HADHA 3030
Affinity Capture-MS Homo sapiens
8 CDC73  
Affinity Capture-MS Homo sapiens
9 MTIF2 4528
Affinity Capture-MS Homo sapiens
10 ASB15 142685
Affinity Capture-MS Homo sapiens
11 SDC1 6382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CD4 920
Affinity Capture-MS Homo sapiens
13 TMEFF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ANAPC15  
Affinity Capture-MS Homo sapiens
15 SLC9A3R1 9368
Affinity Capture-MS Homo sapiens
16 HBA2 3040
Affinity Capture-MS Homo sapiens
17 CD6 923
Affinity Capture-MS Homo sapiens
18 2310003H01Rik  
Affinity Capture-MS Mus musculus
19 TMLHE 55217
Affinity Capture-MS Homo sapiens
20 TARS2 80222
Affinity Capture-MS Homo sapiens
21 H2AFB3  
Affinity Capture-MS Homo sapiens
22 Ncaph  
Affinity Capture-MS Mus musculus
23 NAF1  
Affinity Capture-MS Homo sapiens
24 TCEA2  
Two-hybrid Homo sapiens
25 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CPS1 1373
Affinity Capture-MS Homo sapiens
27 APPBP2  
Two-hybrid Homo sapiens
28 WDR76  
Affinity Capture-MS Homo sapiens
29 HEATR3 55027
Affinity Capture-MS Homo sapiens
30 PASK  
Affinity Capture-MS Homo sapiens
31 ZHX2  
Two-hybrid Homo sapiens
32 Chmp3  
Affinity Capture-MS Mus musculus
33 ARRB1 408
Affinity Capture-MS Homo sapiens
34 MCM2 4171
Affinity Capture-MS Homo sapiens
35 GMEB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 EXOSC5 56915
Two-hybrid Homo sapiens
37 TRIM21 6737
Affinity Capture-MS Homo sapiens
38 FBXW7  
Affinity Capture-MS Homo sapiens
39 ASB18  
Affinity Capture-MS Homo sapiens
40 HIRA  
Affinity Capture-MS Homo sapiens
41 CD44 960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 DDX58 23586
Affinity Capture-RNA Homo sapiens
43 MCCC1 56922
Affinity Capture-MS Homo sapiens
44 ATPAF1  
Affinity Capture-MS Homo sapiens
45 MZF1  
Affinity Capture-MS Homo sapiens
46 MDM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 PPME1 51400
Affinity Capture-MS Homo sapiens
48 TACC3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DHRS2 is involved
No pathways found





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