Gene description for DHRS2
Gene name dehydrogenase/reductase (SDR family) member 2
Gene symbol DHRS2
Other names/aliases HEP27
SDR25C1
Species Homo sapiens
 Database cross references - DHRS2
ExoCarta ExoCarta_10202
Entrez Gene 10202
HGNC 18349
MIM 615194
UniProt Q13268  
 DHRS2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DHRS2
Molecular Function
    carbonyl reductase (NADPH) activity GO:0004090 IDA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to oxidative stress GO:0034599 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of cell proliferation GO:0008285 NAS
    C21-steroid hormone metabolic process GO:0008207 NAS
    response to toxic substance GO:0009636 IDA
    myeloid dendritic cell differentiation GO:0043011 IEP
    oxidation-reduction process GO:0055114 IDA
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IDA
    mitochondrial matrix GO:0005759 IEA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified DHRS2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DHRS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DHRS2 is involved
No pathways found





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