Gene description for FPGS
Gene name folylpolyglutamate synthase
Gene symbol FPGS
Other names/aliases -
Species Homo sapiens
 Database cross references - FPGS
ExoCarta ExoCarta_2356
Vesiclepedia VP_2356
Entrez Gene 2356
HGNC 3824
MIM 136510
UniProt Q05932  
 FPGS identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FPGS
Molecular Function
    tetrahydrofolylpolyglutamate synthase activity GO:0004326 IEA
    ATP binding GO:0005524 IEA
Biological Process
    liver development GO:0001889 IEA
    one-carbon metabolic process GO:0006730 IEA
    nucleobase-containing compound metabolic process GO:0006139 TAS
    small molecule metabolic process GO:0044281 TAS
    organ regeneration GO:0031100 IEA
    folic acid metabolic process GO:0046655 TAS
    vitamin metabolic process GO:0006766 TAS
    tetrahydrofolylpolyglutamate biosynthetic process GO:0046901 IEA
    water-soluble vitamin metabolic process GO:0006767 TAS
    brain development GO:0007420 IEA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IEA
    cytoplasm GO:0005737 TAS
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FPGS in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FPGS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FPGS is involved
No pathways found





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