Gene description for F11
Gene name coagulation factor XI
Gene symbol F11
Other names/aliases FXI
Species Homo sapiens
 Database cross references - F11
ExoCarta ExoCarta_2160
Entrez Gene 2160
HGNC 3529
MIM 264900
UniProt P03951  
 F11 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for F11
Molecular Function
    heparin binding GO:0008201 IEA
    serine-type aminopeptidase activity GO:0070009 IEA
    protein binding GO:0005515 IPI
    serine-type endopeptidase activity GO:0004252 NAS
Biological Process
    positive regulation of fibrinolysis GO:0051919 IDA
    blood coagulation, intrinsic pathway GO:0007597 TAS
    blood coagulation GO:0007596 TAS
    plasminogen activation GO:0031639 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified F11 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for F11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINA5 5104
Reconstituted Complex Homo sapiens
2 GP1BA 2811
Reconstituted Complex Homo sapiens
3 KNG1 3827
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which F11 is involved
PathwayEvidenceSource
Intrinsic Pathway of Fibrin Clot Formation TAS Reactome





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