Gene description for DNAH8
Gene name dynein, axonemal, heavy chain 8
Gene symbol DNAH8
Other names/aliases ATPase
hdhc9
Species Homo sapiens
 Database cross references - DNAH8
ExoCarta ExoCarta_1769
Entrez Gene 1769
HGNC 2952
MIM 603337
UniProt Q96JB1  
 DNAH8 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for DNAH8
Molecular Function
    ATP binding GO:0005524 IEA
    microtubule motor activity GO:0003777 NAS
    ATPase activity GO:0016887 IEA
Biological Process
    cilium or flagellum-dependent cell motility GO:0001539 NAS
    metabolic process GO:0008152 NAS
    microtubule-based movement GO:0007018 IEA
Subcellular Localization
    microtubule GO:0005874 IEA
    dynein complex GO:0030286 IDA
    axonemal dynein complex GO:0005858 NAS
 Experiment description of studies that identified DNAH8 in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DNAH8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH8 is involved
No pathways found





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