Gene description for Igbp1
Gene name immunoglobulin (CD79A) binding protein 1
Gene symbol Igbp1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Igbp1
ExoCarta ExoCarta_58845
Vesiclepedia VP_58845
Entrez Gene 58845
UniProt O08836  
 Igbp1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Igbp1
Molecular Function
    protein phosphatase regulator activity GO:0019888 ISO
    enzyme binding GO:0019899 ISO
    protein domain specific binding GO:0019904 ISO
    mitogen-activated protein kinase kinase binding GO:0031434 ISO
    protein-containing complex binding GO:0044877 IPI
    protein phosphatase 2A binding GO:0051721 IBA
    protein phosphatase 2A binding GO:0051721 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of stress-activated MAPK cascade GO:0032873 ISO
    response to tumor necrosis factor GO:0034612 ISO
    regulation of dephosphorylation GO:0035303 IBA
    positive regulation of dephosphorylation GO:0035306 ISO
    B cell activation GO:0042113 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    regulation of microtubule-based movement GO:0060632 ISO
    response to interleukin-1 GO:0070555 ISO
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO
    negative regulation of apoptotic signaling pathway GO:2001234 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    microtubule GO:0005874 ISO
 Experiment description of studies that identified Igbp1 in exosomes
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Igbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP2CA 5515
Two-hybrid Homo sapiens
2 PPP4C 5531
Two-hybrid Homo sapiens
3 UBR5 51366
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Igbp1 is involved
No pathways found





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