Gene description for PPP1R14B
Gene name protein phosphatase 1, regulatory (inhibitor) subunit 14B
Gene symbol PPP1R14B
Other names/aliases PHI-1
PLCB3N
PNG
SOM172
Species Homo sapiens
 Database cross references - PPP1R14B
ExoCarta ExoCarta_26472
Entrez Gene 26472
HGNC 9057
MIM 601140
UniProt Q96C90  
 PPP1R14B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PPP1R14B
Molecular Function
    protein phosphatase inhibitor activity GO:0004864 IEA
Biological Process
    regulation of phosphorylation GO:0042325 IEA
    negative regulation of catalytic activity GO:0043086 IEA
    innate immune response GO:0045087 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PPP1R14B in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PPP1R14B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPP1R14B is involved
No pathways found





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