Gene description for SLC8A1
Gene name	solute carrier family 8 (sodium/calcium exchanger), member 1
Gene symbol	SLC8A1
Other names/aliases	NCX1
Species	Homo sapiens
Database cross references - SLC8A1
ExoCarta	ExoCarta_6546
Entrez Gene	6546
HGNC	11068
MIM	182305
UniProt	P32418
SLC8A1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for SLC8A1

Molecular Function     ion channel binding GO:0044325 ISS     protein binding GO:0005515 IPI     cytoskeletal protein binding GO:0008092 IDA     calcium:sodium antiporter activity GO:0005432 IMP     metal ion binding GO:0046872 IEA     ankyrin binding GO:0030506 ISS     calmodulin binding GO:0005516 IEA Biological Process     negative regulation of cytosolic calcium ion concentration GO:0051481 ISS     positive regulation of bone mineralization GO:0030501 IMP     cellular response to caffeine GO:0071313 ISS     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 TAS     heart morphogenesis GO:0003007 IEA     ion transport GO:0006811 TAS     calcium ion import GO:0070509 IDA     calcium ion transmembrane transport GO:0070588 IGI     post-embryonic development GO:0009791 IEA     calcium ion transport into cytosol GO:0060402 ISS     calcium ion export GO:1901660 IDA     cardiac muscle cell development GO:0055013 ISS     relaxation of cardiac muscle GO:0055119 TAS     transmembrane transport GO:0055085 TAS     cytosolic calcium ion transport GO:0060401 TAS     regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 TAS     embryonic placenta development GO:0001892 IEA     regulation of heart rate GO:0002027 ISS     sodium ion export GO:0071436 IDA     regulation of the force of heart contraction GO:0002026 ISS     embryonic heart tube development GO:0035050 IEA     sodium ion import GO:0097369 IDA     vascular smooth muscle contraction GO:0014829 ISS     response to muscle stretch GO:0035994 IMP     cardiac muscle contraction GO:0060048 TAS     cellular response to reactive oxygen species GO:0034614 IDA     positive regulation of the force of heart contraction GO:0098735 IMP     muscle contraction GO:0006936 TAS     membrane depolarization during cardiac muscle cell action potential GO:0086012 TAS     regulation of cell communication by electrical coupling GO:0010649 TAS     muscle fiber development GO:0048747 IEA     sodium ion transmembrane transport GO:0035725 IMP     cell communication by electrical coupling involved in cardiac conduction GO:0086064 ISS     calcium ion homeostasis GO:0055074 ISS     relaxation of smooth muscle GO:0044557 ISS     cellular sodium ion homeostasis GO:0006883 IDA     blood coagulation GO:0007596 TAS Subcellular Localization     sarcolemma GO:0042383 ISS     T-tubule GO:0030315 TAS     basolateral plasma membrane GO:0016323 IEA     plasma membrane GO:0005886 TAS     integral component of plasma membrane GO:0005887 IDA     Z disc GO:0030018 ISS     cytosol GO:0005829 ISS     intercalated disc GO:0014704 TAS