Gene description for ATP9A
Gene name ATPase, class II, type 9A
Gene symbol ATP9A
Other names/aliases ATPIIA
Species Homo sapiens
 Database cross references - ATP9A
ExoCarta ExoCarta_10079
Entrez Gene 10079
HGNC 13540
MIM 609126
UniProt O75110  
 ATP9A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ATP9A
Molecular Function
    phospholipid-translocating ATPase activity GO:0004012 IBA
    magnesium ion binding GO:0000287 IEA
    ATP binding GO:0005524 IEA
Biological Process
    metabolic process GO:0008152 IEA
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 IBA
    endocytosis GO:0006897 IBA
    phospholipid translocation GO:0045332 NAS
Subcellular Localization
    early endosome GO:0005769 IDA
    early endosome membrane GO:0031901 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IBA
    trans-Golgi network GO:0005802 IDA
    recycling endosome GO:0055037 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified ATP9A in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP9A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATP9A is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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